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Table 1 Baseline characteristics of women diagnosed with non-metastatic breast cancer between 1996 and 2009 who were registered in the Danish Breast Cancer Group clinical database, and a matched control cohort of cancer-free women from the general population

From: Incidence of hypothyroidism after treatment for breast cancer—a Danish matched cohort study

 

Breast cancer survivors

Matched controls

Numbers

%

Numbers

%

Total

44,574

100.0

203,306

100.0

Calendar year of diagnosis

 1996–1999

11,261

25.3

52,931

26.04

 2000–2003

12,285

27.6

56,836

27.96

 2004–2006

9458

21.2

42,819

21.06

 2007–2009

11,570

26.0

50,720

24.95

Age at breast cancer diagnosis, years

 35–39

1367

3.1

6550

3.22

 40–49

7123

16.0

34,454

16.95

 50–59

12,543

28.1

58,850

28.95

 60–69

12,945

29.0

58,230

28.64

 70–79

7704

17.3

33,091

16.28

 80 or older

2892

6.5

12,131

5.97

Charlson comorbidity index (modified)1

 No

35,832

80.39

173,470

85.32

 Low

7083

15.89

27,111

13.34

 High

1659

3.72

2725

1.34

Menopausal status at diagnosis

 Unknown

62

0.1

  

 Premenopausal

10,833

24.3

  

 Postmenopausal

33,679

75.6

  

Tumour size, mm

 Unknown

2263

5.08

  

 Under 21

24,622

55.24

  

 21–50

16,033

35.97

  

 Over 50

1656

3.72

  

Lymph node status, numbers

 Unknown

2903

6.51

  

 N0

21,757

48.81

  

 N1–3

12,531

28.11

  

 N4+

7383

16.56

  

UICC stage

 Unknown

3244

7.3

  

 I

15,357

34.5

  

 II

18,246

40.9

  

 III

7727

17.3

  

Histological grade

 Unknown

8376

18.79

  

 Low

11,664

26.17

  

 Moderate

16,206

36.36

  

 High

8328

18.68

  

ER status

 Unknown

2562

5.75

  

 ER negative (0–9%)

8320

18.67

  

 ER positive (≥ 10%)

33,692

75.59

  

HER2 status2

 Unknown

28,005

62.83

  

 Negative

13,429

30.13

  

 Positive

3140

7.04

  
  1. 1Charlson comorbidity index (CCI) without cancer included (low: score of 1 or 2; high: score of 3 or more)
  2. 2Systematic recording of HER-2 status started in 2007