Breast Cancer Research

Table 2 Multivariable-adjusted hazard ratios (95% CI) for associations of aspirin and acetaminophen use and risk of breast cancer in the BWHS, overall and by ER status, 1995–2017

From: Aspirin use and risk of breast cancer in African American women

		All invasive (n = 1919)					ER-positive (n = 1112)					ER-negative (n = 569)
	Person-years	Cases	HR^a	95% CI	HR^b	95% CI	Cases	HR^a	95% CI	HR^b	95% CI	Cases	HR^a	95% CI	HR^b	95% CI
Aspirin use
Non-use	676,158	1226	1.00	Reference	1.00	Reference	662	1.00	Reference	1.00	Reference	385	1.00	Reference	1.00	Reference
Past use	143,880	325	0.95	0.83, 1.08	0.97	0.85, 1.10	207	0.97	0.83, 1.14	0.98	0.83, 1.16	92	0.88	0.69, 1.11	0.92	0.72, 1.17
Current use	150,151	368	0.89	0.79, 1.01	0.92	0.81, 1.04	243	0.97	0.83, 1.13	0.98	0.84, 1.15	92	0.77	0.61, 0.98	0.81	0.64, 1.04
Duration of current use
Current, < 5 years	73,790	173	0.91	0.77, 1.07	0.93	0.79, 1.09	108	0.98	0.80, 1.21	1.00	0.81, 1.23	43	0.75	0.55, 1.04	0.79	0.57, 1.09
Current, 5–10 years	41,940	117	0.96	0.79, 1.17	0.98	0.80, 1.19	82	1.09	0.86, 1.38	1.09	0.86, 1.39	28	0.80	0.54, 1.19	0.85	0.57, 1.27
Current, ≥ 10 years	34,422	78	0.77	0.61, 0.91	0.81	0.63, 1.03	53	0.78	0.58, 1.05	0.81	0.60, 1.09	21	0.76	0.48, 1.21	0.82	0.51, 1.31
Acetaminophen use
Non-use	681,495	1340	1.00	Reference	1.00	Reference	755	1.00	Reference	1.00	Reference	406	1.00	Reference	1.00	Reference
Past use	208,818	439	0.94	0.84, 1.05	0.96	0.86, 1.08	283	0.98	0.85, 1.12	0.99	0.86, 1.15	119	0.83	0.67, 1.02	0.87	0.71, 1.08
Current use	79,876	140	0.85	0.71, 1.02	0.88	0.74, 1.05	74	0.86	0.67, 1.09	0.88	0.68, 1.12	44	0.91	0.67, 1.25	0.95	0.69, 1.31

^aAdjusted for age
^bAdjusted for age, first-degree family history of breast cancer, menopausal status, recent BMI, duration of E+P use, parity, age at first birth, age at menarche, recency of OC use, alcohol consumption, physical activity, and lactation

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