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Table 1 Patients characteristics and association with baseline pTKa

From: Plasma thymidine kinase 1 activity and outcome of ER+ HER2− metastatic breast cancer patients treated with palbociclib and endocrine therapy

Characteristics

N (%)

Median TKa Du/L [IQR]

p value

Age

 <  65 years

53 (51)

455 [117–1325]

0.2

 ≥ 65 years

50 (49)

233 [70–705]

Performance status

 0–1

95 (92)

320 [86–865]

0.9

 ≥ 2

8 (8)

247 [150–789]

Grade

 1

15 (15)

482 [99–771]

0.8

 2

61 (61)

292 [117–917]

 3

24 (24)

286 [68–710]

 Missing value

3

 

Progesterone receptor

 Negative

29 (28)

436 [117–1361]

0.1

 Positive

74 (72)

237 [73–546]

Synchronous metastasis

 No

71 (69)

195 [85–640]

0.1

 Yes

32 (31)

476 [111–1292]

Visceral metastasis

 No

35 (34)

249 [116–483]

0.6

 Yes

68 (66)

327 [87–1033]

Primary endocrine resistance

 No

86 (83)

237 [73–588]

0.04

 Yes

17 (17)

758 [233–1641]

Previous chemotherapy

 No

48 (47)

214 [61–781]

0.4

 1 or 2 lines

34 (33)

330 [120–704]

 ≥ 3 lines

21 (20)

466 [157–1281]

  1. All tumors were estrogen receptor-positive
  2. TKa thymidine kinase activity, IQR interquartile range