Impact of a ketogenic diet intervention during radiotherapy on body composition: III—final results of the KETOCOMP study for breast cancer patients

Table 2 Regression coefficients and R² values of the full models fitted to the body composition changes

Covariate	Body weight		Fat mass		Fat free mass		Skeletal muscle mass		50 kHz phase angle
Covariate	Coefficient	p value	Coefficient	p value	Coefficient	p value	Coefficient	p value	Coefficient	p value
Time	0.04 ± 0.05 kg/week	0.40	0.08 ± 0.05 kg/week	0.10	− 0.05 ± 0.04 kg/week	0.22	− 0.01 ± 0.03 kg/week	0.72	0.02 ± 0.01°/week	0.012
KD: yes	− 1.56 ± 0.25 kg	6.9 × 10⁻¹⁰	− 0.35 ± 0.15 kg	0.020	− 1.23 ± 0.27 kg	3.4 × 10⁻⁶	− 0.71 ± 0.19 kg	1.9 × 10⁻⁴	0.17 ± 0.08°	0.038
Time × KD	− 0.42 ± 0.08 kg/week	4.4 × 10⁻⁷	− 0.48 ± 0.08 kg/week	1.5 × 10⁻⁹	0.09 ± 0.07 kg/week	0.19	− 0.02 ± 0.04 kg/week	0.64	− 0.04 ± 0.01°/week	0.0041
Baseline BMI	− 0.49 ± 0.67 kg/10 kg/m²	0.47	0.29 ± 0.53 kg/10 kg/m²	0.58	0.13 ± 0.39 kg/10 kg/m²	0.73	0.55 ± 0.26 kg/10 kg/m²	0.033	0.28 ± 0.10°/10 kg/m²	0.0064
Time × MAP	0.12 ± 0.09 kg/week	0.19	0.15 ± 0.09 kg/week	0.086	− 0.05 ± 0.08 kg/week	0.52	− 0.02 ± 0.05 kg/week	0.60	− 0.01 ± 0.01°/week	0.54
Age	− 0.22 ± 0.11 kg/10 years	0.041	0.09 ± 0.07 kg/10 years	0.19	− 0.26 ± 0.11 kg/10 years	0.025	− 0.20 ± 0.08 kg/10 years	0.012	− 0.13 ± 0.04°/10 years	3.7 × 10⁻⁴
PTV	− 0.15 ± 0.23 kg/500 ccm	0.51	− 0.19 ± 0.13 kg/500 ccm	0.16	0.16 ± 0.25 kg/500 ccm	0.51	0.004 ± 0.16 kg/500 ccm	0.98	− 0.12 ± 0.07°/500 ccm	0.061
Conditional R²	0.999		0.999		0.991		0.986		0.941
Marginal R²	0.992		0.993		0.956		0.942		0.678

Regression coefficient estimates are given with their standard error and associated p value. Note that the average time trends for the SD and KD groups are given by the regression coefficients corresponding to “Time” and “Time” + “Time × KD,” respectively. BMI body mass index, KD ketogenic diet, MAP Master Amino Acid Pattern supplement, PTV planning target volume

ISSN: 1465-542X