Table 3 Univariate and multivariate cox regression disease-free survival
From: Immune parameters associated with survival in metaplastic breast cancer
Parameters | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
HR (95%CI) | p | HR (95%CI) | p | |
Age < 50 vs ≥ 50 | 0.81 (0.27–2.41) | 0.70 | – | – |
Tumor size | ||||
 0–20 | 1 |  | – | – |
 21–50 | 1.03 (0.12–8.99) | 0.98 |  | |
 > 50 | 3.73 (0.74–32.06) | 0.23 |  | |
Lymph node status | ||||
 Positive vs negative | 0.92 (0.28–2.96) | 0.88 | – | – |
Lymphvascular invasion | ||||
 Present vs absent | 3.97 (1.19–13.23) | 0.03 | 3.52 (0.89–13.89) | 0.07 |
With invasive ductal carcinoma (NST) | 0.98 (0.33–2.98) | 0.97 | – | – |
Surgery type | ||||
 BCS vs mastecomy | 1.07 (0.13–8.71) | 0.95 | – | – |
Histological subtype | ||||
 Squamous cell | 1 | 0.58 |  |  |
 Spindle cell | 2.20 (0.25–19.50) |  |  |  |
 Chondriod | 1.36 (0.16–11.68) |  |  |  |
 Osseous | 4.44 (0.84–23.49) |  |  |  |
 Fibromatosis-like | 5.34 (0.61–47.10) |  |  |  |
 Mixed type | 1.31 (0.31–5.49) |  |  |  |
Without/with NST | 1.05 (0.35–3.14) | 0.93 |  |  |
Stromal TILs(/mm2) | ||||
 ≥ 300 vs < 300 | 0.26 (0.07–0.97) | 0.045 | 0.17 (0.04–0.79) | 0.024 |
CD4+ TILs(/mm2) | ||||
 ≥ 250 vs < 250 | 0.12 (0.02–0.93) | 0.042 | 0.99 (0.04–22.43) | 0.99 |
CD8+ TILs(/mm2) | ||||
 ≥ 70 vs < 70 | 0.21 (0.05–0.95) | 0.042 | 0.56 (0.11–2.94) | 0.49 |
Tumoral PDL1 | ||||
 Positive vs negative | 0.19 (0.04–0.85) | 0.03 | 0.39 (0.08–2.03) | 0.26 |
Stromal PD1 | ||||
 Positive vs negative | 0.20 (0.05–0.91) | 0.04 | 1.32 (0.26–6.87) | 0.74 |
TLS | ||||
 Present vs absent | 0.2(0.05–0.75) | 0.014 | 0.61 (0.15–2.59) | 0.51 |
TMIT* vs others | 0.02 (0.01–2.53) | 0.116 |  |  |