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Table 3 Univariate and multivariate cox regression disease-free survival

From: Immune parameters associated with survival in metaplastic breast cancer

Parameters Univariate analysis Multivariate analysis
HR (95%CI) p HR (95%CI) p
Age < 50 vs ≥ 50 0.81 (0.27–2.41) 0.70
Tumor size
 0–20 1  
 21–50 1.03 (0.12–8.99) 0.98  
 > 50 3.73 (0.74–32.06) 0.23  
Lymph node status
 Positive vs negative 0.92 (0.28–2.96) 0.88
Lymphvascular invasion
 Present vs absent 3.97 (1.19–13.23) 0.03 3.52 (0.89–13.89) 0.07
With invasive ductal carcinoma (NST) 0.98 (0.33–2.98) 0.97
Surgery type
 BCS vs mastecomy 1.07 (0.13–8.71) 0.95
Histological subtype
 Squamous cell 1 0.58   
 Spindle cell 2.20 (0.25–19.50)    
 Chondriod 1.36 (0.16–11.68)    
 Osseous 4.44 (0.84–23.49)    
 Fibromatosis-like 5.34 (0.61–47.10)    
 Mixed type 1.31 (0.31–5.49)    
Without/with NST 1.05 (0.35–3.14) 0.93   
Stromal TILs(/mm2)
 300 vs < 300 0.26 (0.07–0.97) 0.045 0.17 (0.04–0.79) 0.024
CD4+ TILs(/mm2)
 250 vs < 250 0.12 (0.02–0.93) 0.042 0.99 (0.04–22.43) 0.99
CD8+ TILs(/mm2)
 70 vs < 70 0.21 (0.05–0.95) 0.042 0.56 (0.11–2.94) 0.49
Tumoral PDL1
 Positive vs negative 0.19 (0.04–0.85) 0.03 0.39 (0.08–2.03) 0.26
Stromal PD1
 Positive vs negative 0.20 (0.05–0.91) 0.04 1.32 (0.26–6.87) 0.74
TLS
 Present vs absent 0.2(0.05–0.75) 0.014 0.61 (0.15–2.59) 0.51
TMIT* vs others 0.02 (0.01–2.53) 0.116   
  1. NST, with invasive carcinoma (no special type)
  2. *TMIT tumor microenviroment type refers to the higher CD8+ TILs and positive PDL1 expression of tumor cells