Fig. 7
From: Therapeutic role of recurrent ESR1-CCDC170 gene fusions in breast cancer endocrine resistance
Silencing of HER2 or SRC increase endocrine responsiveness of HCC1428 cells. a The effect of HER2 silencing on the endocrine responsiveness of HCC1428 cells as shown by clonogenic assays. Western blots verifying the knockdown efficiency and the representative plate images are shown on the right. Intensities of colonies in each well were normalized to the control siRNA and vehicle-treated group. b The effect of SRC silencing on the endocrine responsiveness of HCC1428 cells as shown by clonogenic assays. Western blots verifying the knockdown efficiency and the representative plate images are shown on the right. Intensities of colonies in each well were normalized to the control siRNA and vehicle-treated group. Tam, 4-OH tamoxifen (0.5uM). Ful, Fulvestrant (0.1uM). ***P < 0.001, *P < 0.05 (Student’s t test)