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Fig. 2 | Breast Cancer Research

Fig. 2

From: A risk-associated Active transcriptome phenotype expressed by histologically normal human breast tissue and linked to a pro-tumorigenic adipocyte population

Fig. 2

Normal breast sample scatterplots and TumorMaps of their transcriptome-expressed cancer gene hotspot mutations. As described in the “Methods” section (and detailed in Supplement Table 2), frequencies of the filtered list of detected 567 cancer gene hotspot mutations (variant counts/sample) are plotted: a according to sample batch (F, P) and prior transcriptome assignment as either Active or Inactive, and relative to each sample’s adipocyte or epithelial content (% nuclei) and b onto batch-integrated transcriptome TumorMaps with each sample overlaid by its relative hotspot variant frequency score (red = high) and mapped according to the cancer gene identity (total, TP53, EGFR, or PIK3CA variants)

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