Fig. 2
From: Identification and targeting of selective vulnerability rendered by tamoxifen resistance
High SULT1A1 is the prerequisite for sensitivity to RITA, AF, and ONC-1. a Positive correlation of SULT1A1 mRNA level with sensitivity to RITA, AF, and ONC-1 in NCI-60 cell line database. Each black dot represents a cell line in NCI-60 database (“r” is the Pearson correlation coefficient). b SULT1A1 protein level in cancer cell lines. Breast cancer cells: MCF7, T47D, MDAMB-231; colon cancer: GP5d, HCT116; skin cancer: A431; osteosarcoma: U2OS, SJSA; melanoma: A375, KADA, SKMEL28; lung cancer: H1299. β-Actin was used as loading control. c RITA, AF, and Onc-1 efficiently suppress the growth of high SULT1A1-expressing cells (MCF7, HCT116, GP5d and A431, black solid line) while having negligible effect in cells with low SULT1A1 (A375, KADA, MDAMB-231, SJSA, H1299, red dotted line). Shown are the results obtained after 3 days of treatment, in three independent experiments