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Table 2 Univariate and multivariate analyses for using Cox model for risk of distant relapse according to cancer cell and tumor microenvironment features

From: A subset of activated fibroblasts is associated with distant relapse in early luminal breast cancer

  Univariate analyses Multivariate analyses
  HR CI95% [] p value HR CI95% [] p value
CDH1
 Range 250–300 Ref Ref
 Per decrease of 50 pts 1.21 [1.03–1.44] 0.02 1.23 [1.007–1.51] 0.04
ROR risk category
 Low risk Ref Ref
 Intermediary risk 1.98 [0.98–4.00] 0.05 1.68 [0.75–3.76] 0.20
 High risk 2.45 [1.20–4.98] 0.01 1.62 [0.67–3.91] 0.28
CAF subset
 S1 3.98 [2.09–7.59] < 0.0001 5.02 [2.34–10.73] < 0.0001
 S2, S3, or S4 Ref Ref
CD4+lymphocytes
 Low 1.88 [1.07–3.30] 0.02 2.973 [1.50–5.88] 0.001
 High Ref Ref
Macrophages
 Low Ref Ref
 High 1.84 [1.04–3.22] 0.03 1.60 [0.83–3.09] 0.15
CD31+vessels
 Low Ref Ref
 High 1.73 [0.99–3.07] 0.05 2.56 [1.32–4.97] 0.005
  1. Level of markers was determined using the median H score
  2. Lobular carcinomas were excluded from analysis using E-cadherin (N = 12)
  3. CAF cancer-associated fibroblasts, CI confidence interval, HR hazard ratio, Pts points