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Table 2 Univariate and multivariate analyses for using Cox model for risk of distant relapse according to cancer cell and tumor microenvironment features

From: A subset of activated fibroblasts is associated with distant relapse in early luminal breast cancer

 

Univariate analyses

Multivariate analyses

 

HR

CI95% []

p value

HR

CI95% []

p value

CDH1

 Range 250–300

Ref

Ref

 Per decrease of 50 pts

1.21

[1.03–1.44]

0.02

1.23

[1.007–1.51]

0.04

ROR risk category

 Low risk

Ref

Ref

 Intermediary risk

1.98

[0.98–4.00]

0.05

1.68

[0.75–3.76]

0.20

 High risk

2.45

[1.20–4.98]

0.01

1.62

[0.67–3.91]

0.28

CAF subset

 S1

3.98

[2.09–7.59]

< 0.0001

5.02

[2.34–10.73]

< 0.0001

 S2, S3, or S4

Ref

Ref

CD4+lymphocytes

 Low

1.88

[1.07–3.30]

0.02

2.973

[1.50–5.88]

0.001

 High

Ref

Ref

Macrophages

 Low

Ref

Ref

 High

1.84

[1.04–3.22]

0.03

1.60

[0.83–3.09]

0.15

CD31+vessels

 Low

Ref

Ref

 High

1.73

[0.99–3.07]

0.05

2.56

[1.32–4.97]

0.005

  1. Level of markers was determined using the median H score
  2. Lobular carcinomas were excluded from analysis using E-cadherin (N = 12)
  3. CAF cancer-associated fibroblasts, CI confidence interval, HR hazard ratio, Pts points