From: A subset of activated fibroblasts is associated with distant relapse in early luminal breast cancer
Univariate analyses | Multivariate analyses | |||||
---|---|---|---|---|---|---|
HR | CI95% [] | p value | HR | CI95% [] | p value | |
CDH1 | ||||||
Range 250–300 | Ref | – | – | Ref | – | – |
Per decrease of 50 pts | 1.21 | [1.03–1.44] | 0.02 | 1.23 | [1.007–1.51] | 0.04 |
ROR risk category | ||||||
Low risk | Ref | – | – | Ref | – | – |
Intermediary risk | 1.98 | [0.98–4.00] | 0.05 | 1.68 | [0.75–3.76] | 0.20 |
High risk | 2.45 | [1.20–4.98] | 0.01 | 1.62 | [0.67–3.91] | 0.28 |
CAF subset | ||||||
S1 | 3.98 | [2.09–7.59] | < 0.0001 | 5.02 | [2.34–10.73] | < 0.0001 |
S2, S3, or S4 | Ref | – | – | Ref | – | – |
CD4+lymphocytes | ||||||
Low | 1.88 | [1.07–3.30] | 0.02 | 2.973 | [1.50–5.88] | 0.001 |
High | Ref | – | – | Ref | – | – |
Macrophages | ||||||
Low | Ref | – | – | Ref | – | – |
High | 1.84 | [1.04–3.22] | 0.03 | 1.60 | [0.83–3.09] | 0.15 |
CD31+vessels | ||||||
Low | Ref | – | – | Ref | – | – |
High | 1.73 | [0.99–3.07] | 0.05 | 2.56 | [1.32–4.97] | 0.005 |