Skip to main content

Table 1 Patients characteristics

From: A subset of activated fibroblasts is associated with distant relapse in early luminal breast cancer

  Global population (n = 104) Controls (n = 52) Cases (n = 52) p value
Age at diagnosis 55 [32; 86] 55.5 [32; 86] 54.5 [38; 82] 0.77a
BMI (kg/m2) 23.9 [17.3; 44.1] 24.1 [17.3; 44.1] 23.8 [19.1; 41.6] 0.96a
Tumor size (in mm) 15 [6; 20] 15 [6; 20] 15 [10; 20] 0.59a
 T1b 11 (10.6%) 5 (9.6%) 6 (11.5%) 1b
 T1c 93 (89.4%) 47 (90.4%) 46 (88.5%)  
Histological subtype     0.29b
 N.S.T. 87 (83.6%) 42 (80.8%) 45 (86.5%)  
 Lobular 11 (10.6%) 8 (15.4%) 3 (5.8%)  
 Mixed 1 (1%) 0 1 (1.9%)  
 Other 5 (4.8%) 2 (3.8%) 3 (5.8%)  
Grade     0.86b
 I 23 (22.1%) 12 (23.1%) 11 (21.2%)  
 II 57 (54.8%) 27 (51.9%) 30 (57.6%)  
 III 24 (23.1%) 13 (25%) 11 (21.2%)  
Neoplastic emboli 33 (35.1%) 14 (31.1%) 19 (38.8%) 0.51b
Intraductal carcinoma 75 (72.1%) 35 (67.3%) 40 (76.9%) 0.38b
ER (%) 80 [14; 100] 80 [20; 100] 85 [14; 100] 0.64 a
PR (%) 60 [0; 100] 65 [0; 100] 60 [0; 100] 0.33 a
HER2 score     0.90b
 0 73 (70.2%) 36 (69.2%) 37 (71.2%)  
 + 22 (21.2%) 12 (23.1%) 10 (19.2%)  
 ++ ISH − 9 (8.7%) 4 (7.7%) 5 (9.6%)  
Ki67 (%) 19 [1; 70] 21 [1; 60] 16.5 [5; 70] 0.65 a
Mitotic index 8.5 [0; 100] 8 [0; 100] 9.5 [1; 60] 0.78 a
Surgical treatment     
 Lumpectomy 95 (91.3%) 50 (96.2%) 45 (86.5%) 0.16b
 Total mastectomy 9 (8.7%) 2 (3.8%) 7 (13.5%)  
 Sentinel lymph node biopsy 53 (51%) 30 (57.7%) 23 (44.2%) 0.23b
 Axillary lymphadenectomy 51 (49%) 22 (42.3%) 29 (55.8%)  
Other treatments     
 Chemotherapy 23 (22.1%) 13 (25%) 10 (19.2%) 0.63b
 Radiotherapy 91 (87.5%) 49 (94.2%) 42 (80.8%) 0.07b
 Endocrine therapy 96 (92.3%) 48 (92.3%) 48 (92.3%) 1b
Evolution     
 Local relapse 11 (10.6%) 0 11 (21.2%) 0.0005b
 Controlateral relapse 3 (2.9%) 0 3 (5.8%) 0.24b
 Axillary lymph node relapse 5 (4.8%) 0 5 (9.6%) 0.05b
 Distant relapse 52 (50%) 0 52 (100%)  
  Bone metastases 41 (39.4%) 0 41 (78.8%)  
  Visceral metastases 24 (23%) 0 24 (46.2%)  
Death 31 (29.8%) 0 31 (59.6%) < 0.0001b
  1. aMann-Whitney test to compare controls and cases
  2. bFisher exact test to compare controls and cases
  3. BMI body mass index, ER estrogen receptor, PR progesterone receptor