Table 1 Patient characteristics and clinicopathological features of tumors
Breast cancer primaries with ophthalmic metastasis identified through TIES (absolute number + percentage) N = 28 | Metastatic breast cancer in the UPMC Network Cancer Registry (absolute number + percentage) N = 1366 | p value | |
|---|---|---|---|
Age | |||
Median age at diagnosis of primary | 55 | 53 | 0.4455 |
< 50 at diagnosis | 10 (35.7%) | 520 (38.1%) | 0.847 |
≥ 50 at diagnosis | 18 (64.3%) | 846 (61.9%) | |
Race | 1 | ||
White | 26 (92.9%) | 1248 (91.4%) | |
Black | 2 (7.1%) | 104 (7.6%) | |
Others | 0 | 14 (1.0%) | |
Survival (median in month) | |||
Overall survival | 82.1 | 58.8 | 0.47 |
Disease-free survival | 26.4 | 35.4 | 0.52 |
Distant metastasis-free survival | 34.2 | 36.6 | 0.76 |
Histological subtypes | 0.00067 | ||
IDC | 14 (50.0%) | 1167 (85.4%) | |
ILC | 9 (32.1%) | 155 (11.3%) | |
Mixed | 2 (7.1%) | 44 (3.2%) | |
Unknown | 3 (10.7%) | 0 | |
Stage | 0.00106 | ||
Stage 0 | 11 (0.8%) | ||
Stage I | 0 (0%) | 340 (24.9%) | |
Stage II | 5 (17.9%) | 573 (41.9%) | |
Stage III | 7 (25.0%) | 186 (13.6%) | |
Stage IV | 7 (25.0%) | 184 (13.5%) | |
Stage unknown | 9 (32.1%) | 72 (5.3%) | |
Lymph node status | 0.04927 | ||
Positive | 18 (64.3%) | 814 (59.6%) | |
Negative | 2 (7.1%) | 386 (28.3%) | |
Unknown | 8 (28.6%) | 166 (12.2%) | |
ER status | 0.2597 | ||
ER+ | 21 (75.0%) | 981 (71.8%) | |
ER− | 4 (14.3%) | 385 (28.2%) | |
Unknown | 3 (10.7%) | 0 | |
PR status | 0.2809 | ||
PR+ | 17 (60.7%) | 805 (58.9%) | |
PR− | 6 (21.4%) | 519 (38.0%) | |
PR unknown | 5 (17.9%) | 42 (3.1%) | |
HER2 status | 1 | ||
HER2/neu + | 3 (10.7%) | 51 (3.7%) | |
HER2/neu − | 20 (71.4%) | 277 (20.3%) | |
Equivocal | 0 | 9 (0.7%) | |
HER2/neu unknown | 5 (17.9%) | 1029 (75.3%) | |