Table 3 Associations between crown-like structures in breast adipose tissue (CLS-B) and clinical outcomes among 319 women diagnosed with invasive breast cancer (stages I–III) at Emory University between 2007 and 2012 with follow-up data through December 31, 2018
Exposure | Outcome | Category | Cases/person-years | Age-adjusted HR (95% CI) | Multivariable-adjusted HR (95% CI) |
|---|---|---|---|---|---|
Any CLS-Ba,b | Overall survival | No | 32/1635 | 1.00 (−) | 1.00 (−) |
Yes | 18/726 | 1.12 (0.63–1.99) | 1.02 (0.55–1.87) | ||
CLS-B density (CLS-B/cm2)b | None | 32/1635 | 1.00 (−) | 1.00 (−) | |
Low (< 0.87) | 13/371 | 1.47 (0.77–2.82) | 1.35 (0.68–2.68) | ||
High (≥ 0.87) | 5/355 | 0.69 (0.27–1.76) | 0.63 (0.24–1.65) | ||
Any CLS-Ba,b | Progression-free survival | No | 47/1538 | 1.00 (−) | 1.00 (−) |
Yes | 24/704 | 1.05 (0.64–1.72) | 0.99 (0.59–1.67) | ||
CLS-B density (CLS-B/cm2)b | None | 47/1538 | 1.00 (−) | 1.00 (−) | |
Low (< 0.87) | 14/362 | 1.15 (0.63–2.09) | 1.08 (0.58–2.02) | ||
High (≥ 0.87) | 10/341 | 0.95 (0.48–1.88) | 0.90 (0.45–1.81) |