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Table 2 Distribution of tumor characteristics and CAP1 tumor-specific expression

From: Effects of tumor-specific CAP1 expression and body constitution on clinical outcomes in patients with early breast cancer

  Patients with tumor in TMA
(n = 718)
 
Patient characteristics All patients Low CAP1 Moderate CAP1 High CAP1 Ptrend Non-assessable Not included
n (%) or median (IQR) (n = 910) (n = 106) (n = 273) (n = 290) (n = 49) in TMA (n = 192)
Age at diagnosis
 Continuous [years] 65.0 (60.0–71.6) 65.4 (60.8–73.3) 66.6 (61.4–72.3) 63.9 (58.8–69.5) < 0.001a 60.7 (55.0–66.4) 65.6 (60.4–71.9)
Tumor size [mm]
 ≤ 20 637 (71.8) 64 (60.4) 189 (69.5) 205 (71.2) 0.066b 40 (83.3) 139 (80.3)
 > 20 250 (28.2) 42 (39.6) 83 (30.5) 83 (28.8) 8 (16.7) 34 (19.7)
 Missing 19 0 0 0   0 19
Axillary node involvement
 Negative 557 (68.0) 65 (63.7) 168 (63.9) 181 (67.0) 0.453b 36 (80.0) 107 (77.0)
 Positive (≥ 1) 262 (32.0) 37 (36.3) 95 (36.1) 89 (33.0) 9 (20.0) 32 (23.0)
 Missing 53 0 0 0   0 53
Histological grade
 I 227 (27.2) 12 (11.4) 55 (20.6) 99 (34.5) < 0.001b 14 (33.3) 47 (35.1)
 II 392 (46.9) 48 (45.7) 128 (47.9) 138 (48.1) 17 (40.5) 61 (45.5)
 III 216 (25.9) 45 (42.9) 84 (31.5) 50 (17.4) 11 (26.2) 26 (19.4)
 Missing 75 1 6 3   7 58
Ki67 status
 Low 258 (40.7) 27 (30.7) 62 (29.2) 118 (54.4) < 0.001b 11 (39.3) 40 (45.5)
 Intermediate 196 (31.0) 26 (29.5) 76 (35.8) 65 (30.0) 6 (21.4) 23 (26.1)
 High 179 (28.3) 35 (39.8) 74 (34.9) 34 (15.7) 11 (39.3) 25 (28.4)
 Missing 277 18 61 73   21 104
ER status
 Positive (> 10%) 701 (88.8) 79 (79.0) 235 (90.0) 246 (90.1) 0.014b 31 (81.6) 110 (94.0)
 Negative (≤ 10%) 88 (11.2) 21 (21.0) 26 (10.0) 27 (9.9) 7 (18.4) 7 (6.0)
 Missing 121 6 12 17   11 75
PR status
 Positive (> 10%) 438 (58.2) 47 (49.0) 165 (65.7) 147 (56.5) 0.729b 19 (50.0) 60 (56.1)
 Negative (≤ 10%) 314 (41.8) 49 (51.0) 86 (34.3) 113 (43.5) 19 (50.0) 47 (43.9)
 Missing 158 10 22 30   11 85
HER2 status
 HER2+ 65 (9.2) 14 (16.9) 19 (7.9) 21 (8.3) 0.071b 3 (9.1) 8 (8.1)
 HER2− 645 (90.8) 69 (83.1) 223 (92.1) 232 (91.7) 30 (90.9) 91 (91.9)
 Missing 200 23 31 37   16 93
Molecular subtypes
 Luminal A-like 352 (55.4) 29 (37.2) 110 (49.3) 148 (66.4) < 0.001b 13 (46.4) 52 (62.7)
 Luminal B-like 159 (25.0) 21 (26.9) 70 (31.4) 38 (17.0) 9 (32.1) 21 (25.3)
 HER2+ 65 (10.2) 14 (17.9) 19 (8.5) 21 (9.4) 3 (10.7) 8 (9.6)
 Triple-negative 59 (9.3) 14 (17.9) 24 (10.8) 16 (7.2) 3 (10.7) 2 (2.4)
 Missing 275 28 50 67   21 109
  1. aJonckheere-Terpstra test
  2. bLinear-by-linear association test. P value < 0.05 in bold