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Table 2 Univariable and multivariable analysis of 562 LNN breast cancer patients (METABRIC dataset [13]) used to examine prognostic value of EMAT subtype designation status for 10-year follow-up

From: Superior breast cancer metastasis risk stratification using an epithelial-mesenchymal-amoeboid transition gene signature

  Univariable analysis Multivariable (age, tumor
size, grade, IHC status**,
any chemo/hormonal/
radiation therapy)
Multivariable (age, tumor
size, grade, PAM50 status#,
any chemo/hormonal/
radiation therapy)
Multivariable (age, tumor
size, grade, EMAT status##,
any chemo/hormonal/
radiation therapy)
n P HR (95% CI) n P HR (95% CI) n P HR (95% CI) n P HR (95% CI)
Age 562 0.70 1.00 (0.99–1.02) 510 0.18 1.014 (0.99–1.03) 521 0.21 1.01 (0.99–1.03) 521 0.21 1.01 (0.99–1.03)
Tumor size (< 2, 2–5, > 5) 559 0.02 1.67 (1.10–2.54) 510 0.04 1.59 (1.04–2.45) 521 0.03 1.60 (1.04–2.49) 521 0.04 1.59 (1.03–2.47)
Tumor grade* 524 0.20 1.26 (0.89–1.79) 510 0.46 1.16 (0.78–1.71) 521 0.45 1.16 (0.78–1.73) 521 0.98 1.01 (0.69–1.47)
Any chemotherapy 562 0.15 1.78 (0.82–3.87) 510 0.17 1.86 (0.78–4.451) 521 0.12 1.99 (0.84–4.77) 521 0.10 2.07 (0.87–4.92)
Any hormonal therapy 562 0.15 0.72 (0.46–1.12) 510 0.06 0.62 (0.38–1.01) 521 0.04 0.60 (0.37–0.97) 521 0.05 0.62 (0.39–1.00)
Any radiation therapy 562 0.20 0.76 (0.50–1.16) 510 0.28 0.78 (0.50–1.22) 521 0.24 0.77 (0.49–1.19) 521 0.15 0.72 (0.46–1.12)
IHC status** 538 0.03 1.23 (1.02–1.47) 510 0.32 1.11 (0.90–1.37)       
PAM50 status# 562 0.12 1.14 (0.97–1.35)     521 0.67 1.04 (0.86–1.27)    
EMAT status## 562 1E−4 1.65 (1.29–2.11)        521 3E−4 1.64 (1.25–2.14)
  1. Two-sided p-values were based on χ2 or Fisher’s exact test, whenever appropriate
  2. CI confidence interval, ER estrogen receptor, HER2 human epidermal growth factor receptor 2, HR hazard ratio, PR progesterone receptor, P p-value, n number of samples
  3. *(Low - “1,” intermediate - “2,” high - “3”)
  4. **(ER+HER2− “1,” ER+HER2+ “2,” ER−HER2+ “3,” ER−HER2− “4”)
  5. #(Normal-like - “0,” LumA - “1,” LumB - “2,” HER2 - “3,” basal-like - “4”)
  6. ##(EMAT1 - “1,” EMAT2 - “2,” EMAT3 - “3,” EMAT4 - “4”)