| TC | TCIC | IC | sTIL level | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Factors | Negative | Positive | Fisher | Negative | Positive | Fisher | Negative | Positive | Fisher | Low | High | Fisher |
N (%) | N (%) | P value | N (%) | N (%) | P value | N (%) | N (%) | P value | N (%) | N (%) | P value | |
Age | [N = 141] |  | [N = 131] |  | [N = 131] |  | [N = 145] |  | ||||
 < 50 years | 50 (94) | 3 (6) | 0.535 | 45 (88) | 6 (12) | 0.1651 | 47 (92) | 4 (8) | 0.1257 | 41 (73) | 15 (27) | 0.557 |
 ≥ 50 years | 79 (90) | 9 (10) |  | 62 (78) | 18 (23) |  | 65 (81) | 15 (19) |  | 69 (78) | 20 (22) |  |
Race/ethnicity | [N = 141] |  | [N = 131] |  | [N = 131] |  | [N = 145] |  | ||||
 Black | 19 (79) | 5 (21) | 0.0228 | 18 (75) | 6 (25) | 0.5126 | 20 (83) | 4 (17) | 0.9225 | 16 (70) | 7 (30) | 0.6991 |
 White+Latino | 97 (95) | 5 (5) |  | 78 (84) | 15 (16) |  | 80 (86) | 13 (14) |  | 82 (77) | 24 (23) |  |
 Others | 13 (87) | 2 (13) |  | 11 (79) | 3 (21) |  | 12 (86) | 2 (14) |  | 12 (75) | 4 (25) |  |
Histologic type | [N = 141] |  | [N = 131] |  | [N = 131] |  | [N = 145] |  | ||||
 IDC | 106 (91) | 10 (9) | 0.0737 | 85 (79) | 22 (21) | 0.0624 | 89 (83) | 18 (17) | 0.2508 | 87 (73) | 33 (28) | 0.1731 |
 ILC | 17 (100) | 0 (0) |  | 16 (100) | 0 (0) |  | 16 (100) | 0 (0) |  | 16 (94) | 1 (6) |  |
 Metaplastic | 3 (60) | 2 (40) |  | 3 (60) | 2 (40) |  | 4 (80) | 1 (20) |  | 4 (80) | 1 (20) |  |
 Mixed IDC/ILC | 3 (100) | 0 (0) |  | 3 (100) | 0 (0) |  | 3 (100) | 0 (0) |  | 3 (100) | 0 (0) |  |
Histologic gradea | [N = 141] |  | [N = 131] |  | [N = 131] |  | [N = 145] |  | ||||
 1 + 2 | 68 (100) | 0 (0) | 0.0003 | 62 (95) | 3 (5) | 0.0001 | 62 (95) | 3 (5) | 0.0022 | 65 (88) | 9 (12) | 0.0008 |
 3 | 61 (84) | 12 (16) |  | 45 (68) | 21 (32) |  | 50 (76) | 16 (24) |  | 45 (63) | 26 (37) |  |
sTIL level | [N = 139] |  | [N = 131] |  | [N = 131] |  | NA |  | ||||
 < 10% | 102 (97) | 3 (3) | 0.0002 | 89 (91) | 9 (9) | < 0.0001 | 90 (92) | 8 (8) | 0.0006 |  |  |  |
 ≥ 10% | 25 (74) | 9 (26) |  | 16 (52) | 15 (48) |  | 20 (65) | 11 (35) |  |  |  |  |
ER | [N = 141] |  | [N = 131] |  | [N = 131] |  | [N = 145] |  | ||||
 Negative | 30 (77) | 9 (23) | 0.0005 | 20 (57) | 15 (43) | < 0.0001 | 24 (69) | 11 (31) | 0.0019 | 22 (56) | 17 (44) | 0.0018 |
 Positive | 99 (97) | 3 (3) |  | 87 (91) | 9 (9) |  | 88 (92) | 8 (8) |  | 88 (83) | 18 (17) |  |
PR | [N = 141] |  | [N = 131] |  | [N = 131] |  | [N = 145] |  | ||||
 Negative | 48 (83) | 10 (17) | 0.0037 | 34 (67) | 17 (33) | 0.0009 | 39 (76) | 12 (24) | 0.0236 | 36 (62) | 22 (38) | 0.0026 |
 Positive | 81 (98) | 2 (2) |  | 73 (91) | 7 (9) |  | 73 (91) | 7 (9) |  | 74 (85) | 13 (15) |  |
HER2 | [N = 141] |  | [N = 131] |  | [N = 131] |  | [N = 145] |  | ||||
 Negative | 118 (91) | 12 (9) | 0.5987 | 98(81) | 23 (19) | 0.6881 | 103 (85) | 18 (15) | 1 | 99 (75) | 33 (25) | 0.7344 |
 Positive | 11 (100) | 0 (0) |  | 9(90) | 1 (10) |  | 9 (90) | 1 (10) |  | 11 (85) | 2 (15) |  |
TNBC | [N = 141] |  | [N = 131] |  | [N = 131] |  | [N = 145] |  | ||||
 No | 101 (97) | 3 (3) | 0.0003 | 88 (91) | 9 (9) | < 0.0001 | 89 (92) | 8 (8) | 0.0014 | 90 (83) | 18 (17) | 0.0007 |
 Yes | 28 (76) | 9 (24) |  | 19 (56) | 15 (44) |  | 23 (68) | 11 (32) |  | 20 (54) | 17 (46) |  |
Receptor group | [N = 141] |  | [N = 131] |  | [N = 131] |  | [N = 145] |  | ||||
 ER/PR pos | 90 (97) | 3 (3) | 0.0012 | 79 (91) | 8 (9) | 0.0001 | 80 (92) | 7 (8) | 0.0038 | 79 (83) | 16 (17) | 0.0023 |
 HER2 | 11 (100) | 0 (0) |  | 9 (90) | 1 (10) |  | 9 (90) | 1 (10) |  | 11 (85) | 2 (15) |  |
 TNBC | 28 (76) | 9 (24) |  | 19 (56) | 15 (44) |  | 23 (68) | 11 (32) |  | 20 (54) | 17 (46) |  |
Tumor size | [N = 141] |  | [N = 131] |  | [N = 131] |  | [N = 145] |  | ||||
 ≤ 2 cm | 26 (84) | 5 (16) | 0.2433 | 19 (73) | 7 (27) | 0.4286 | 20 (77) | 6 (23) | 0.3765 | 21 (62) | 13 (38) | 0.049 |
 > 2 to 5 cm | 54 (93) | 4 (7) |  | 49 (84) | 9 (16) |  | 51 (88) | 7 (12) |  | 43 (75) | 14 (25) |  |
 > 5 cm | 49 (94) | 3 (6) |  | 39 (83) | 8 (17) |  | 41 (87) | 6 (13) |  | 46 (85) | 8 (15) |  |
ypN | [N = 141] |  | [N = 131] |  | [N = 131] |  | [N = 145] |  | ||||
 (y)pN0 | 39 (85) | 7 (15) | 0.0921 | 33 (77) | 10 (23) | 0.6247 | 36 (84) | 7 (16) | 0.9424 | 35 (74) | 12 (26) | 0.3048 |
 (y)pN1 | 45 (96) | 2 (4) |  | 36 (84) | 7 (16) |  | 36 (84) | 7 (16) |  | 37 (74) | 13 (26) |  |
 (y)pN2 | 22 (88) | 3 (12) |  | 19 (79) | 5 (21) |  | 21 (88) | 3 (13) |  | 18 (69) | 8 (31) |  |
 (y)pN3 | 23 (100) | 0 (0) |  | 19 (90) | 2 (10) |  | 19 (90) | 2 (10) |  | 20 (91) | 2 (9) |  |
pM | [N = 141] |  | [N = 131] |  | [N = 131] |  | [N = 145] |  | ||||
 0 | 119 (91) | 12 (9) | 1 | 101 (82) | 22 (18) | 0.6382 | 106 (86) | 17 (14) | 0.3272 | 100 (74) | 35 (26) | 0.1184 |
 1 | 10 (100) | 0 (0) |  | 6 (75) | 2 (25) |  | 6 (75) | 2 (25) |  | 10 (100) | 0 (0) |  |
RCB category | [N = 140] |  | [N = 130] |  | [N = 130] |  | [N = 144] |  | ||||
 I | 4 (80) | 1 (20) | 0.5155 | 3 (75) | 1 (25) | 0.4125 | 3 (75) | 1 (25) | 0.2473 | 5 (83) | 1 (17) | 0.9425 |
 II | 63 (91) | 6 (9) |  | 54 (86) | 9 (14) |  | 57 (90) | 6 (10) |  | 56 (77) | 17 (23) |  |
 III | 61 (92) | 5 (8) |  | 49 (78) | 14 (22) |  | 51 (81) | 12 (19) |  | 48 (74) | 17 (26) |  |