Table 1 Association of PD-L1 staining with clinicopathologic factors in all patients without neoadjuvant chemotherapy
| Â | TC | TCIC | IC | sTIL level | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Factors | Negative | Positive | Fisher | Negative | Positive | Fisher | Negative | Positive | Fisher | Low | High | Fisher |
N (%) | N (%) | P value | N (%) | N (%) | P value | N (%) | N (%) | P value | N (%) | N (%) | P value | |
Age | [N = 341] |  | [N = 340] |  | [N = 340] |  | [N = 345] |  | ||||
 < 50 years | 81 (88) | 11 (12) | 0.5411 | 68 (75) | 23 (25) | 0.2256 | 71 (78) | 20 (22) | 0.1466 | 60 (63) | 35 (37) | 0.0153 |
 ≥ 50 years | 226 (91) | 23 (9) |  | 202 (81) | 47 (19) |  | 211 (85) | 38 (15) |  | 191 (76) | 59 (24) |  |
Race/ethnicity | [N = 341] |  | [N = 340] |  | [N = 340] |  | [N = 345] |  | ||||
 Black | 34 (83) | 7 (17) | 0.1159 | 20 (49) | 21 (51) | < 0.0001 | 21 (51) | 20 (49) | < 0.0001 | 17 (41) | 24 (59) | < 0.0001 |
 White+Latino | 257 (91) | 24 (9) |  | 235 (84) | 45 (16) |  | 246 (88) | 34 (12) |  | 219 (77) | 66 (23) |  |
 Others | 16 (84) | 3 (16) |  | 15 (79) | 4 (21) |  | 15 (79) | 4 (21) |  | 15 (79) | 4 (21) |  |
Histologic type | [N = 340] |  | [N = 339] |  | [N = 339] |  | [N = 344] |  | ||||
 IDC | 261 (90) | 29 (10) | 1 | 225 (78) | 64 (22) | 0.262 | 233 (81) | 56 (19) | 0.0121 | 200 (68) | 92 (32) | < 0.0001 |
 ILC | 34 (89) | 4 (11) |  | 34 (89) | 4 (11) |  | 37 (97) | 1 (3) |  | 36 (95) | 2 (5) |  |
 Metaplastic | 0 (0) | 0 (0) |  | 0 (0) | 0 (0) |  | 0 (0) | 0 (0) |  | 0 (0) | 0 (0) |  |
 Mixed IDC/ILC | 11 (92) | 1 (8) |  | 10 (83) | 2 (17) |  | 11 (92) | 1 (8) |  | 14 (100) | 0 (0) |  |
Histologic grade | [N = 340] |  | [N = 339] |  | [N = 339] |  | [N = 344] |  | ||||
 1 + 2 | 216 (96) | 10 (4) | < 0.0001 | 200 (88) | 26 (12) | < 0.0001 | 208 (92) | 18(8) | < 0.0001 | 201 (87) | 30 (13) | < 0.0001 |
 3 | 90 (79) | 24 (21) |  | 69 (61) | 44 (39) |  | 73 (65) | 40 (35) |  | 49 (43) | 64 (57) |  |
sTIL level | [N = 337] |  | [N = 337] |  | [N = 337] |  | NA |  | ||||
 < 10% | 233 (95) | 12 (5) | < 0.0001 | 226 (92) | 19 (8) | < 0.0001 | 235 (96) | 10 (4) | < 0.0001 |  |  |  |
 ≥ 10% | 70 (76) | 22 (24) |  | 42 (46) | 50 (54) |  | 44 (48) | 48 (52) |  |  |  |  |
ER | [N = 341] |  | [N = 340] |  | [N = 340] |  | [N = 345] |  | ||||
 Negative | 60 (86) | 10 (14) | 0.1828 | 46 (66) | 24 (34) | 0.0026 | 48 (69) | 22 (31) | 0.0011 | 27 (39) | 43 (61) | < 0.0001 |
 Positive | 247 (91) | 24 (9) |  | 224 (83) | 46 (17) |  | 234 (87) | 36 (13) |  | 224 (81) | 51 (19) |  |
PR | [N = 341] |  | [N = 340] |  | [N = 340] |  | [N = 342] |  | ||||
 Negative | 95 (84) | 18 (16) | 0.0125 | 73 (65) | 40 (35) | < 0.0001 | 78 (69) | 35 (31) | < 0.0001 | 54 (48) | 59 (52) | < 0.0001 |
 Positive | 212 (93) | 16 (7) |  | 197 (87) | 30 (13) |  | 204 (90) | 23 (10) |  | 197 (85) | 35 (15) |  |
HER2 | [N = 338] |  | [N = 337] |  | [N = 337] |  | [N = 342] |  | ||||
 Negative | 278 (91) | 29 (9) | 0.2195 | 248 (81) | 58 (19) | 0.0178 | 257 (84) | 49 (16) | 0.0801 | 231 (75) | 78 (25) | 0.0071 |
 Positive | 26 (84) | 5 (16) |  | 19 (61) | 12 (39) |  | 22 (71) | 9 (29) |  | 17 (52) | 16 (48) |  |
TNBC | [N = 338] |  | [N = 337] |  | [N = 337] |  | [N = 342] |  | ||||
 No | 250 (90) | 28 (10) | 1 | 226 (81) | 52 (19) | 0.0518 | 238 (86) | 40 (14) | 0.0069 | 227 (80) | 56 (20) | < 0.0001 |
 Yes | 54 (90) | 6 (10) |  | 41 (69) | 18 (31) |  | 41 (69) | 18 (31) |  | 21 (36) | 38 (64) |  |
Receptor group | [N = 338] |  | [N = 337] |  | [N = 337] |  | [N = 342] |  | ||||
 ER/PR pos | 224 (91) | 23 (9) | 0.4491 | 207 (84) | 40 (16) | 0.0022 | 216 (87) | 31 (13) | 0.0009 | 210 (84) | 40 (16) | < 0.0001 |
 HER2 | 26 (84) | 5 (16) |  | 19 (61) | 12 (39) |  | 22 (71) | 9 (29) |  | 17 (52) | 16 (48) |  |
 TNBC | 54 (90) | 6 (10) |  | 41 (69) | 18 (31) |  | 41 (69) | 18 (31) |  | 21 (36) | 38 (64) |  |
Tumor size | [N = 340] |  | [N = 339] |  | [N = 339] |  | [N = 344] |  | ||||
 ≤ 2 cm | 176 (92) | 16 (8) | 0.34 | 157 (81) | 36 (19) | 0.3325 | 162 (84) | 31 (16) | 0.5449 | 151 (77) | 46 (23) | 0.0517 |
 > 2 to 5 cm | 105 (87) | 16 (13) |  | 90 (75) | 30 (25) |  | 96 (80) | 24 (20) |  | 79 (65) | 43 (35) |  |
 > 5 cm | 25 (93) | 2 (7) |  | 22 (85) | 4 (15) |  | 23 (88) | 3 (12) |  | 20 (80) | 5 (20) |  |
pN | [N = 338] |  | [N = 337] |  | [N = 337] |  | [N = 342] |  | ||||
 (y)pN0 | 207 (90) | 22 (10) | 0.4972 | 185 (80) | 45 (20) | 0.5121 | 191 (83) | 39 (17) | 0.882 | 169 (73) | 62 (27) | 0.9442 |
 (y)pN1 | 81 (91) | 8 (9) |  | 70 (80) | 18 (20) |  | 73 (83) | 15 (17) |  | 65 (71) | 26 (29) |  |
 (y)pN2 | 10 (91) | 1 (9) |  | 8 (73) | 3 (27) |  | 9 (82) | 2 (18) |  | 8 (67) | 4 (33) |  |
 (y)pN3 | 7 (78) | 2 (22) |  | 5 (63) | 3 (38) |  | 6(75) | 2 (25) |  | 6 (75) | 2 (25) |  |
pM | [N = 338] |  | [N = 337] |  | [N = 337] |  | [N = 342] |  | ||||
 0 | 301 (90) | 32 (10) | 0.4036 | 265 (80) | 68 (20) | 1 | 275 (83) | 58 (17) | 1 | 245 (72) | 93 (28) | 1 |
 1 | 4 (80) | 1 (20) |  | 3 (75) | 1 (25) |  | 4 (100) | 0 (0) |  | 3 (75) | 1 (25) |  |
pStage | [N = 336] |  | [N = 335] |  | [N = 335] |  | [N = 340] |  | ||||
 I | 163 (92) | 15 (8) | 0.2829 | 150 (84) | 29 (16) | 0.1412 | 156 (87) | 23 (13) | 0.1034 | 142 (78) | 40 (22) | 0.0637 |
 II | 111 (90) | 13 (10) |  | 92 (75) | 31 (25) |  | 95 (77) | 28 (23) |  | 80 (65) | 44 (35) |  |
 III | 24 (83) | 5 (17) |  | 21 (72) | 8 (28) |  | 23 (79) | 6 (21) |  | 22 (73) | 8 (27) |  |
 IV | 4 (80) | 1 (20) |  | 3 (75) | 1 (25) |  | 4 (100) | 0 (0) |  | 3 (75) | 1 (25) |  |