Fig. 6

Effect of the overexpression of ALX4 and WDR86 on the malignant properties of BT-474 and MDA-MB-231 cells. Growth of breast cancer cells of BT-474 (a) and MDA-MB-231 (b). Migration capacity of breast cancer cells of BT-474 (c) and MDA-MB-231 (d). Colony-forming capacity of breast cancer cells of BT-474 (e) and MDA-MB-231 (f). Comparison of tumor volume over time (g) and final tumor weight (h) between control and ALX4- or WDR86-overexpressing BT-474 cell-inoculated mice. Data are presented as the mean ± sem from three measurements (a–f) or nine tumors (g, h). Two-sample t tests were used to compare the means of the control and each knockdown group.*P < 0.05; **P < 0.005