Fig. 3

Loss of FAK kinase function reduces survival of MMTV-Wnt1-driven basal-like mammary tumors. a Representative images of Ctrl-Wnt1, cKD-Wnt1, and cKO-Wnt tumors immunostained for Ki67 and corresponding quantification of percentage of positive cells per field of view (n = 4 for each genotype). b Representative images of Ctrl-Wnt1, cKD-Wnt1, and cKO-Wnt tumors immunostained for cleaved caspase 3 and corresponding quantification of percentage of positive cells per field of view (Ctrl-Wnt1, cKD-Wnt n = 8; cKO-Wnt n = 7). c Representative images of Ctrl-Wnt1, cKD-Wnt1, and cKO-Wnt tumors immunostained for CD31 and corresponding quantification of percentage of CD31-positive area per field of view (n = 3). d Representative images of Ctrl-Wnt1, cKD-Wnt1, and cKO-Wnt tumors immunostained for CD8 and corresponding quantification of percentage of CD8-positive cells per field of view (Ctrl-Wnt1 n = 7; cKD-Wnt, cKO-Wnt n = 5). All statistical tests for c–f include ANOVA followed by Tukey’s multiple comparisons test, *p < 0.05, **p ≤ 0.01