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Fig. 1 | Breast Cancer Research

Fig. 1

From: FAK activates AKT-mTOR signaling to promote the growth and progression of MMTV-Wnt1-driven basal-like mammary tumors

Fig. 1

Elevated FAK expression is associated with worse patient prognosis and are more prevalent in basal-like breast cancers. a Kaplan–Meier survival plot from analysis of the METABRIC dataset of overall survival curve of breast cancer patients with or without FAK gene amplification. Log-rank test, **p < 0.01. b Analysis of percentage of patients with FAK gene amplification across all prediction analysis of microarray 50 (PAM50) classified breast cancer subtypes in METABRIC dataset. Fisher’s exact test, ****p (basal vs other subtypes) < 0.0001. c Analysis of percentage of patients with high FAK mRNA across all PAM50 classified breast cancer subtypes in METABRIC dataset. Chi-square test, ****p (basal vs other subtypes) < 0.0001. d Boxplot representation of FAK mRNA expression levels in the PAM50 subtypes. One-way ANOVA, basal-like versus other subtypes, ***p < 0.001

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Breast Cancer Research

ISSN: 1465-542X

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