TY - STD TI - Sørlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci. 2001;98(19):10869-74. ID - ref1 ER - TY - STD TI - Perou CM. Molecular stratification of triple-negative breast cancers. Oncologist. 2010;15(Suppl 5):39–48. https://doi.org/10.1634/theoncologist.2010-S5-39. UR - https://doi.org/10.1634/theoncologist.2010-S5-39 ID - ref2 ER - TY - STD TI - Clevers H. Wnt/β-catenin signaling in development and disease. Cell. 2006;127(3):469-80. https://doi.org/10.1016/j.cell.2006.10.018. ID - ref3 ER - TY - STD TI - Tsukamoto AS, Grosschedl R, Guzman RC, Parslow T, Varmus HE. Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice. Cell. 1988;55(4):619–25. https://doi.org/10.1016/0092-8674(88)90220-6. ID - ref4 ER - TY - STD TI - Herschkowitz JI, Simin K, Weigman VJ, Mikaelian I, Usary J, Hu Z, et al. Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biol. 2007;8(5):R76. https://doi.org/10.1186/gb-2007-8-5-r76. ID - ref5 ER - TY - STD TI - Lim E, Wu D, Pal B, Bouras T, Asselin-Labat ML, Vaillant F, et al. Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways. Breast Cancer Res. 2010;12(2):R21. https://doi.org/10.1186/bcr2560. ID - ref6 ER - TY - STD TI - Guan JL. Focal adhesion kinase in integrin signaling. Matrix Biol. 1997;16(4):195–200. https://doi.org/10.1016/s0945-053x(97)90008-1. ID - ref7 ER - TY - JOUR AU - Sulzmaier, F. J. AU - Jean, C. AU - Schlaepfer, D. D. PY - 2014 DA - 2014// TI - FAK in cancer: mechanistic findings and clinical applications JO - Nat Rev Cancer VL - 14 UR - https://doi.org/10.1038/nrc3792 DO - 10.1038/nrc3792 ID - Sulzmaier2014 ER - TY - JOUR AU - Nagy, T. AU - Luo, M. AU - Guan, J. -. L. AU - Liu, S. AU - Fan, H. AU - Wei, H. PY - 2009 DA - 2009// TI - Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells JO - Cancer Res VL - 69 UR - https://doi.org/10.1158/0008-5472.CAN-08-3078 DO - 10.1158/0008-5472.CAN-08-3078 ID - Nagy2009 ER - TY - JOUR AU - Lahlou, H. AU - Sanguin-Gendreau, V. AU - Zuo, D. AU - Cardiff, R. D. AU - McLean, G. W. AU - Frame, M. C. PY - 2007 DA - 2007// TI - Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression JO - Proc Natl Acad Sci U S A VL - 104 UR - https://doi.org/10.1073/pnas.0710091104 DO - 10.1073/pnas.0710091104 ID - Lahlou2007 ER - TY - STD TI - Provenzano PP, Inman DR, Eliceiri KW, Beggs HE, Keely PJ. Mammary epithelial-specific disruption of focal adhesion kinase retards tumor formation and metastasis in a transgenic mouse model of human breast cancer. Am J Pathol. 2008;173(5):1551–65. [cited 2019 Mar 30] Available from: http://www.ncbi.nlm.nih.gov/pubmed/18845837. UR - http://www.ncbi.nlm.nih.gov/pubmed/18845837 ID - ref11 ER - TY - JOUR AU - Lazaro, G. AU - Smith, C. AU - Goddard, L. AU - Jordan, N. AU - McClelland, R. AU - Barrett-Lee, P. PY - 2013 DA - 2013// TI - Targeting focal adhesion kinase in ER+/HER2+ breast cancer improves trastuzumab response JO - Endocr Relat Cancer VL - 20 UR - https://doi.org/10.1530/ERC-13-0019 DO - 10.1530/ERC-13-0019 ID - Lazaro2013 ER - TY - STD TI - Lahlou H, Sanguin-Gendreau V, Frame MC, Muller WJ. Focal adhesion kinase contributes to proliferative potential of ErbB2 mammary tumour cells but is dispensable for ErbB2 mammary tumour induction in vivo. Breast Cancer Res. 2012;14(1):R36. Published 2012 Feb 28. https://doi.org/10.1186/bcr3131. ID - ref13 ER - TY - STD TI - Shen M, Jiang YZ, Wei Y, Ell B, Sheng X, Esposito M, et al. Tinagl1 suppresses triple-negative breast cancer progression and metastasis by simultaneously inhibiting integrin/FAK and EGFR signaling. Cancer Cell. 2019;35(1):64–80.e7. https://doi.org/10.1016/j.ccell.2018.11.016. ID - ref14 ER - TY - STD TI - Golubovskaya VM, Ylagan L, Miller A, Hughes M, Wilson J, Wang D, et al. High focal adhesion kinase expression in breast carcinoma is associated with lymphovascular invasion and triple-negative phenotype. BMC Cancer. 2014;14:769. https://doi.org/10.1186/1471-2407-14-769. ID - ref15 ER - TY - STD TI - Tai YL, Chu PY, Lai IR, Wang MY, Tseng HY, Guan JL, et al. An EGFR/Src-dependent β4 integrin/FAK complex contributes to malignancy of breast cancer. Sci Rep. 2015;5:16408. https://doi.org/10.1038/srep16408. ID - ref16 ER - TY - STD TI - Zhao J, Guan JL. Signal transduction by focal adhesion kinase in cancer. Cancer Metastasis Rev. 2009;28:35–49. https://doi.org/10.1007/s10555-008-9165-4. ID - ref17 ER - TY - STD TI - Provenzano PP, Inman DR, Eliceiri KW, Beggs HE, Keely PJ. Mammary epithelial-specific disruption of focal adhesion kinase retards tumor formation and metastasis in a transgenic mouse model of human breast cancer. Am J Pathol. 2008;173(5):1551–65. https://doi.org/10.2353/ajpath.2008.080308. ID - ref18 ER - TY - STD TI - Lim ST, Chen XL, Lim Y, Hanson DA, Vo TT, Howerton K, et al. Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation. Mol Cell. 2008;29(1):9–22. https://doi.org/10.1016/j.molcel.2007.11.031. ID - ref19 ER - TY - STD TI - Chen Y, Wei H, Liu F, Guan JL. Hyperactivation of mammalian target of rapamycin complex 1 (mTORC1) promotes breast cancer progression through enhancing glucose starvation-induced autophagy and Akt signaling. J Biol Chem. 2014. 289(2):1164–73. https://doi.org/10.1074/jbc.M113.526335. ID - ref20 ER - TY - STD TI - Saxton RA, Sabatini DM. mTOR signaling in growth, metabolism, and disease. Cell. 2017;168(6):960-76. https://doi.org/10.1016/j.cell.2017.02.004. ID - ref21 ER - TY - STD TI - Mossmann D, Park S, Hall MN. mTOR signalling and cellular metabolism are mutual determinants in cancer. Nat Rev Cancer. 2018;18(12):744–57. https://doi.org/10.1038/s41568-018-0074-8. ID - ref22 ER - TY - STD TI - Tancioni I, Miller NLG, Uryu S, Lawson C, Jean C, Chen XL, et al. FAK activity protects nucleostemin in facilitating breast cancer spheroid and tumor growth. Breast Cancer Res. 2015;17:47. Published 2015 Mar 28. https://doi.org/10.1186/s13058-015-0551-x. ID - ref23 ER - TY - STD TI - Gan B, Yoo Y, Guan JL. Association of focal adhesion kinase with tuberous sclerosis complex 2 in the regulation of S6 kinase activation and cell growth. J Biol Chem. 2006;281(49):37321–9. https://doi.org/10.1074/jbc.M605241200. ID - ref24 ER - TY - JOUR AU - Shen, T. L. AU - Park, A. Y. J. AU - Alcaraz, A. AU - Peng, X. AU - Jang, I. AU - Koni, P. PY - 2005 DA - 2005// TI - Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis JO - J Cell Biol VL - 169 UR - https://doi.org/10.1083/jcb.200411155 DO - 10.1083/jcb.200411155 ID - Shen2005 ER - TY - STD TI - Zhao X, Peng X, Sun S, Park AYJ, Guan J-L. Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development. J Cell Biol. 2010;189(6):955–65. Available from: https://doi.org/10.1083/jcb.200912094. ID - ref26 ER - TY - JOUR AU - Luo, M. AU - Zhao, X. AU - Chen, S. AU - Liu, S. AU - Wicha, M. S. AU - Guan, J. L. PY - 2013 DA - 2013// TI - Distinct FAK activities determine progenitor and mammary stem cell characteristics JO - Cancer Res VL - 73 UR - https://doi.org/10.1158/0008-5472.CAN-13-1351 DO - 10.1158/0008-5472.CAN-13-1351 ID - Luo2013 ER - TY - STD TI - Wagner KU, Wall RJ, St-Onge L, et al. Cre-mediated gene deletion in the mammary gland. Nucleic Acids Res. 1997;25(21):4323–30. https://doi.org/10.1093/nar/25.21.4323. ID - ref28 ER - TY - STD TI - Li Y, Podsypanina K, Liu X, et al. Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice. BMC Mol Biol. 2001;2:2. https://doi.org/10.1186/1471-2199-2-2. ID - ref29 ER - TY - STD TI - Nagy T, Wei H, Shen TL, Peng X, Liang CC, Gan B, et al. Mammary epithelial-specific deletion of the focal adhesion kinase gene leads to severe lobulo-alveolar hypoplasia and secretory immaturity of the murine mammary gland. J Biol Chem. 2007;282(43):31766–76. https://doi.org/10.1074/jbc.M705403200. ID - ref30 ER - TY - STD TI - Wei H, Wang C, Croce CM, Guan JL. p62/SQSTM1 synergizes with autophagy for tumor growth in vivo. Genes Dev. 2014;28(11):1204–16. https://doi.org/10.1101/gad.237354.113. ID - ref31 ER - TY - STD TI - Pereira B, Chin SF, Rueda OM, Vollan HKM, Provenzano E, Bardwell HA, et al. The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes. Nat Commun. 2016;7:11479. Published 2016 May 10. https://doi.org/10.1038/ncomms11479. ID - ref32 ER - TY - STD TI - Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, et al. The cBio Cancer Genomics Portal: an open platform for exploring multidimensional cancer genomics data.  Cancer Discov. 2012;2(5):401–4. https://doi.org/10.1158/2159-8290.CD-12-0095. ID - ref33 ER - TY - STD TI - Yeo SK, Paul R, Haas M, Wang C, Guan JL. Improved efficacy of mitochondrial disrupting agents upon inhibition of autophagy in a mouse model of BRCA1-deficient breast cancer. Autophagy. 2018;14(7):1214–25. https://doi.org/10.1080/15548627.2018.1460010. ID - ref34 ER - TY - STD TI - Bernard PS, Parker JS, Mullins M, Cheung MCU, Leung S, Voduc D, et al. Supervised risk predictor of breast cancer based on intrinsic subtypes. J Clin Oncol. 2009;27(8):1160-7. https://doi.org/10.1200/JCO.2008.18.1370. ID - ref35 ER - TY - STD TI - Kumar MS, Pester RE, Chen CY, et al. Dicer1 functions as a haploinsufficient tumor suppressor. Genes Dev. 2009;23(23):2700–4. https://doi.org/10.1101/gad.1848209. ID - ref36 ER - TY - STD TI - Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005;307(5712):1098-101. https://doi.org/10.1126/science.1106148. ID - ref37 ER - TY - STD TI - Pylayeva Y, Gillen KM, Gerald W, Beggs HE, Reichardt LF, Giancotti FG. Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling. J Clin Invest. 2009;119(2):252–66. [cited 2019 Mar 30] Available from: http://www.ncbi.nlm.nih.gov/pubmed/19147981. UR - http://www.ncbi.nlm.nih.gov/pubmed/19147981 ID - ref38 ER - TY - STD TI - Roberts WG, Ung E, Whalen P, Cooper B, Hulford C, Autry C, et al. Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271. Cancer Res. 2008;68(6):1935–44. https://doi.org/10.1158/0008-5472.CAN-07-5155. ID - ref39 ER - TY - STD TI - Fallahi-Sichani M, Honarnejad S, Heiser LM, Gray JW, Sorger PK. Metrics other than potency reveal systematic variation in responses to cancer drugs. Nat Chem Biol. 2013;9(11):708-14. https://doi.org/10.1038/nchembio.1337. ID - ref40 ER - TY - STD TI - Gunther EJ, Moody SE, Belka GK, Hahn KT, Innocent N, Dugan KD, et al. Impact of p53 loss on reversal and recurrence of conditional Wnt-induced tumorigenesis. Genes Dev. 2003;17(4):488–501. https://doi.org/10.1101/gad.1051603. ID - ref41 ER - TY - STD TI - Gao C, Chen G, Kuan S-F, Zhang DH, Schlaepfer DD, Hu J. FAK/PYK2 promotes the Wnt/β-catenin pathway and intestinal tumorigenesis by phosphorylating GSK3β. Cooper JA, editor. Elife. 2015;4:e10072. Available from: https://doi.org/10.7554/eLife.10072. ID - ref42 ER - TY - STD TI - Real S, Meo-Evoli N, Espada L, Tauler A. E2F1 regulates cellular growth by mTORC1 signaling. PLoS One. 2011;6(1):e16163. Published 2011 Jan 24. https://doi.org/10.1371/journal.pone.0016163. ID - ref43 ER - TY - STD TI - Iadevaia V, Liu R, Proud CG. MTORC1 signaling controls multiple steps in ribosome biogenesis. Semin Cell Dev Biol. 2014;36:113-20. https://doi.org/10.1016/j.semcdb.2014.08.004. ID - ref44 ER - TY - STD TI - Chen HC, Appeddu PA, Isoda H, Guan JL. Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase. J Biol Chem. 1996;271(42):26329–34. https://doi.org/10.1074/jbc.271.42.26329. ID - ref45 ER - TY - STD TI - Inoki K, Ouyang H, Zhu T, Lindvall C, Wang Y, Zhang X, et al. TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell. 2006;126(5):955–68. https://doi.org/10.1016/j.cell.2006.06.055. ID - ref46 ER - TY - STD TI - Banerjee K, Keasey MP, Razskazovskiy V, Visavadiya NP, Jia C, Hagg T. Reduced FAK-STAT3 signaling contributes to ER stress-induced mitochondrial dysfunction and death in endothelial cells. Cellular signalling, ISSN 1873-3913. 36:154–162. https://doi.org/10.1016/j.cellsig.2017.05.007. ID - ref47 ER -