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Table 2 TNBC subtypes based on the FUSCC classification criteria

From: Triple-negative breast cancer molecular subtyping and treatment progress

FUSCC classification GO terms/canonical pathway Most upregulated lncRNAs Correlated mRNA TNBC cell line
IM Cytokine-cytokine receptor interaction↑
T cell receptor signaling pathway ↑
B cell receptor signaling pathway ↑
Chemokine signaling pathway ↑
NF-kappa B signaling pathway ↑
ENST00000443397 LOC100653210, LOC100653245, IGHV3-20, IGHV4-31, IGHJ1, IGKV3-7. MDA-MB-231
LAR Steroid hormone biosynthesis ↑
Porphyrin and chlorophyll metabolism ↑
PPAR signaling pathway ↑
Androgen and estrogen metabolism ↑
ENST00000447908 TRIM2, SDR16C5, C1QTNF3, KRT17, SERPINB5, TFAP2B, FAR2, CYP39A1, KIAA1467, EDDM3B. HS578T
MES ECM-receptor interaction ↑
Focal adhesion ↑
TGF-beta signaling pathway ↑
ABC transporter ↑
Adipocytokine signaling pathway ↑
NR_003221 SELP, CNN1, ADH1B. HCC1937
BLIS Mitotic cell cycle↑
Mitotic prometaphase↑
M phase of mitotic cell cycle↑
DNA replication↑
DNA repair↑
Immune response↓
Innate immune response ↓
T cell receptor signaling ↓
TCONS_00000027 RNASE6, MS4A6A, MTBP, FGFR2, CXor161, DHTKD1, IGLV6-57, BARD1, PRTFDC1. MDA-MB-436
  1. Data from Yi-Rong Liu et al. [23]
  2. Abbreviations: FUSCC Fudan University Shanghai Cancer Center, IM immunomodulatory, LAR luminal androgen receptor, MES mesenchymal-like, BLIS basal-like and immune suppressed, BL basal-like, M claudin-low-enriched mesenchymal, MSL mesenchymal stem-like, ECM extracellular matrix, TGF transforming growth factor