Table 2 TNBC subtypes based on the FUSCC classification criteria
From: Triple-negative breast cancer molecular subtyping and treatment progress
FUSCC classification | GO terms/canonical pathway | Most upregulated lncRNAs | Correlated mRNA | TNBC cell line |
|---|---|---|---|---|
IM | Cytokine-cytokine receptor interaction↑ T cell receptor signaling pathway ↑ B cell receptor signaling pathway ↑ Chemokine signaling pathway ↑ NF-kappa B signaling pathway ↑ | ENST00000443397 | LOC100653210, LOC100653245, IGHV3-20, IGHV4-31, IGHJ1, IGKV3-7. | MDA-MB-231 |
LAR | Steroid hormone biosynthesis ↑ Porphyrin and chlorophyll metabolism ↑ PPAR signaling pathway ↑ Androgen and estrogen metabolism ↑ | ENST00000447908 | TRIM2, SDR16C5, C1QTNF3, KRT17, SERPINB5, TFAP2B, FAR2, CYP39A1, KIAA1467, EDDM3B. | HS578T |
MES | ECM-receptor interaction ↑ Focal adhesion ↑ TGF-beta signaling pathway ↑ ABC transporter ↑ Adipocytokine signaling pathway ↑ | NR_003221 | SELP, CNN1, ADH1B. | HCC1937 |
BLIS | Mitotic cell cycle↑ Mitotic prometaphase↑ M phase of mitotic cell cycle↑ DNA replication↑ DNA repair↑ Immune response↓ Innate immune response ↓ T cell receptor signaling ↓ | TCONS_00000027 | RNASE6, MS4A6A, MTBP, FGFR2, CXor161, DHTKD1, IGLV6-57, BARD1, PRTFDC1. | MDA-MB-436 |