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Table 3 Best supported circulating differentially expressed miRNAs based on overlap with databases (CMEP, dbDEMC and miRCancer) and miRNA-mRNA interactions networks

From: Secreted breast tumor interstitial fluid microRNAs and their target genes are associated with triple-negative breast cancer, tumor grade, and immune infiltration

miRNA

BC vs Normal

Luminal/HER2 vs TNBC

ER+ vs ER-

PgR+ vs PgR-

High TILs vs Low TILs

High TILs vs Low TILs & High Gr vs Low/Medium Gr

High Gr vs Low/Medium Gr

Metastasis

Poor Outcome

hsa-let-7a-5p

Up

Down

.

.

.

.

.

.

.

hsa-let-7f-5p

Up

Down

.

.

.

.

.

.

.

hsa-let-7g-5p

Up

Down

.

.

.

.

.

.

.

hsa-miR-103a-3p

Down

.

.

.

.

Down

.

.

.

hsa-miR-106a-5p

Up

.

.

.

.

Up

.

Up

.

hsa-miR-106b-3p

Up

.

.

.

.

Up

.

Up

.

hsa-miR-106b-5p

Up

.

.

.

.

Up

.

Up

.

hsa-miR-107

Up

Down

.

.

Up

Up

Up

Up

.

hsa-miR-1260a

Up

.

.

.

Up

Up

.

Up

.

hsa-miR-127-3p

Up

.

.

.

.

.

.

.

.

hsa-miR-136-5p

Down

.

.

.

.

Down

.

Down

.

hsa-miR-138-5p

Up

.

.

.

Up

Up

.

.

.

hsa-miR-141-3p

Up

Down

.

.

Up

Up

.

Up

.

hsa-miR-146a-5p

Up

.

.

.

.

Down

.

.

.

hsa-miR-151a-5p

Up

.

.

.

.

.

.

.

.

hsa-miR-15b-5p

Up

Down

.

.

Up

Up

.

Up

.

hsa-miR-17-5p

Up

Down

.

.

Up

Up

.

Up

.

hsa-miR-186-5p

Up

.

.

.

Up

Up

.

Up

.

hsa-miR-18a-5p

Up

.

.

.

.

Up

Up

.

.

hsa-miR-190b

Up

.

Up

.

.

Up

.

.

.

hsa-miR-19b-3p

Up

.

.

.

.

Up

.

.

.

hsa-miR-222-3p

Up

.

.

.

.

Up

.

.

.

hsa-miR-23a-3p

Up

.

.

.

Up

Up

.

.

.

hsa-miR-299-5p

Down

.

.

.

Down

Down

.

Down

.

hsa-miR-29b-3p

Up

Down

.

.

.

.

.

.

.

hsa-miR-301a-3p

Up

Down

.

.

Up

Up

Up

Up

Up

hsa-miR-30d-5p

Up

Down

.

.

.

Up

.

Up

.

hsa-miR-342-3p

Up

.

Up

.

.

.

.

.

.

hsa-miR-342-5p

Up

.

Up

.

.

.

.

.

.

hsa-miR-34c-5p

Up

.

.

.

.

.

.

.

.

hsa-miR-374a-5p

Up

.

.

Down

.

.

.

.

.

hsa-miR-376a-3p

Up

.

.

.

.

Down

.

.

.

hsa-miR-423-5p

Up

.

.

.

.

.

.

.

.

hsa-miR-424-5p

Up

.

.

.

.

Up

.

.

.

hsa-miR-454-3p

Up

.

.

.

.

Up

Up

Up

.

hsa-miR-494-3p

Down

Up

.

.

.

Down

.

Down

.

hsa-miR-518e-3p

Up

.

Up

Down

.

.

.

.

.

hsa-miR-520d-3p

Up

.

.

.

.

.

.

.

.

hsa-miR-589-5p

Up

.

.

.

.

.

.

.

.

hsa-miR-590-3p

Up

Down

.

Down

.

.

.

.

.

hsa-miR-638

Up

.

.

Up

.

.

.

.

.

hsa-miR-744-3p

Up

Down

.

.

.

.

.

.

.

hsa-miR-9-3p

Up

Down

.

.

Up

.

.

.

.

hsa-miR-92a-3p

Up

.

.

.

.

.

.

.

.

hsa-miR-941

Up

.

.

.

.

Up

Up

Up

Up

hsa-miR-10b-5p

.

Down

.

.

Up

Up

.

.

.

hsa-miR-140-3p

.

Down

.

Down

.

.

.

.

.

hsa-miR-148a-3p

.

Down

.

.

Up

Up

.

.

Up

hsa-miR-222-5p

.

Down

.

Down

.

.

.

.

.

hsa-miR-452-5p

.

Down

Down

.

.

.

.

.

.

hsa-miR-29b-2-5p

.

.

Up

.

.

.

.

.

.

hsa-miR-32-5p

.

.

Up

.

.

Up

.

Up

Up

hsa-miR-922

.

.

Up

Down

.

.

.

.

.

hsa-miR-126-3p

.

.

.

Down

.

.

.

.

.

hsa-miR-29c-3p

.

.

.

Down

.

.

.

.

.

hsa-miR-432-3p

.

.

.

Down

.

.

.

.

.

hsa-miR-450b-5p

.

.

.

Down

.

.

.

.

.

hsa-miR-629-5p

.

.

.

Down

.

.

.

.

.

hsa-miR-10a-5p

.

.

.

.

Up

Up

Up

.

.

hsa-miR-129-5p

.

.

.

.

Up

.

.

.

.

hsa-miR-149-3p

.

.

.

.

Up

.

.

.

.

hsa-miR-182-3p

.

.

.

.

Up

.

.

.

.

hsa-miR-19a-3p

.

.

.

.

Up

Up

.

.

.

hsa-miR-432-5p

.

.

.

.

Up

Up

.

.

.

hsa-miR-720

.

.

.

.

Up

.

.

.

.

hsa-miR-130b-3p

.

.

.

.

.

Up

.

Up

Up

hsa-miR-130b-5p

.

.

.

.

.

Up

.

Up

.

hsa-miR-135a-5p

.

.

.

.

.

Up

.

.

.

hsa-miR-16-5p

.

.

.

.

.

Up

.

Up

.

hsa-miR-20a-5p

.

.

.

.

.

Up

.

.

.

hsa-miR-20b-5p

.

.

.

.

.

Up

.

.

.

hsa-miR-301b-3p

.

.

.

.

.

Up

Up

Up

.

hsa-miR-30b-5p

.

.

.

.

.

Up

.

.

.

hsa-miR-369-3p

.

.

.

.

.

Down

.

Down

.

hsa-miR-874

.

.

.

.

.

Down

.

.

.

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Breast Cancer Research

ISSN: 1465-542X

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