Secreted breast tumor interstitial fluid microRNAs and their target genes are associated with triple-negative breast cancer, tumor grade, and immune infiltration

Table 1 Sample summary table

	Levels	Number	Percent	Sum %
miRNA	No	37	26.4	26.4
miRNA	Yes	103	73.6	100.0
mRNA	No	64	45.7	45.7
mRNA	Yes	76	54.3	100.0
Tumor percentage	40	2	1.4	1.4
	60	29	20.7	22.1
	80	58	41.4	63.6
	N	51	36.4	100.0
Grade	1	5	3.6	3.6
	2	46	33.3	36.9
	3	36	26.1	63.0
	N	51	37.0	100.0
Her2	0	23	16.4	16.4
	1+	18	12.9	29.3
	2+	28	20.0	49.3
	3+	20	14.3	63.6
	N	51	36.4	100.0
ER	ER⁻	20	14.3	14.3
	ER⁺	69	49.3	63.6
	N	51	36.4	100.0
PgR	PgR⁻	40	28.6	65.0
	PgR⁺	49	35.0	36.4
	N	51	36.4	100.0
AR	AR⁻	28	20.0	20.0
	AR⁺	57	40.7	60.7
	N	51	39.3	100.0
Sample type	Normal	51	36.4	36.4
Sample type	Tumor	89	63.6	100.0
Subtype	Her2-enriched (Her2)	11	7.9	7.9
	Luminal A (LumA)	42	30.0	37.9
	Luminal B (LumB)	13	9.3	47.1
	Luminal B Her2-enriched (LumB-Her2)	13	9.3	56.4
	Triple-negative breast cancer (TNBC)	10	7.1	92.9
	Normal	51	36.4	100.0
TIL score	0	17	12.1	12.1
	1+	25	17.9	30.0
	2+	30	21.4	51.4
	3+	17	12.1	63.6
	N	51	36.4	100.0
Metastasis	0	71	50.7	50.7
	1	18	12.9	63.6
	N	51	36.4	100.0
	All	140	100.0	100.0

The letter N denotes normal samples. miRNA = TIF miRNA data (yes, no); mRNA = tumor tissue mRNA expression data (yes, no); Tumor percentage = percentage of tumor tissue in sample, tumor grade (1, 2, or 3); Her2 = Her2 receptor status (0, 1, 2, or 3); ER = estrogen receptor status (+, −); PgR = progesterone receptor status (+, −); AR = androgen receptor status (+, −). Sample type (tumor, normal); subtype –luminal A, luminal B, luminal B, Her2-enriched, triple-negative breast cancer, or normal. TIL score = tumor-infiltrating lymphocyte score (0, 1, 2, or 3); metastasis—0 is no metastasis and 1 is metastasis; outcome—patient outcome, where 0 is alive and 1 is deceased. The biological characteristics of all samples used were retrieved from [49, 50]

ISSN: 1465-542X