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Fig. 1 | Breast Cancer Research

Fig. 1

From: Secreted breast tumor interstitial fluid microRNAs and their target genes are associated with triple-negative breast cancer, tumor grade, and immune infiltration

Fig. 1

Sample clustering and results of differential abundance/expression analysis. a, bK-means clustering of tumor interstitial fluid miRNAs (a) and tissue mRNAs (b). Both sets display two clusters: cluster 1—hormone receptor-negative samples (ER− and PgR−), high grade (grade 3), and high TILs (T2, T3); cluster 2—hormone receptor-positive samples (ER+, PgR+), lower grade (grades 1 and 2), and low TILs (T0, T1). c, d Differentially abundant miRNA from normal and tumor interstitial fluids (c) and mRNA from tumor biopsies (d). Upset plots show the set size for each comparison and redundancy of these miRNAs: up, FDR < 0.05 and logFC > 1; down, FDR < 0.05 and logFC < − 1. Sets: (1) TIF vs NIF, (2) subtypes (luminal A vs TNBC, luminal B vs TNBC, and Her2 vs TNBC), (3) estrogen positive vs negative tumors, (4) progesterone positive vs negative tumors, (5) tumor grade 3 vs tumor grade 1/2, and (6) K-means cluster 1 vs cluster 2

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