Ultrafast dynamic contrast-enhanced breast MRI may generate prognostic imaging markers of breast cancer

Breast Cancer Research

Table 4 Maximum slope and bolus arrival time according to invasive cancer characteristics

	No. of lesions^†	Maximum slope (mmol/s)			Bolus arrival time (s)
		Median	IQR	P value	Median	IQR	P value
Tumor grade	111			0.552			0.025*
Grade 3	56 (50)	0.034	0.022–0.054		21.3	19.3–23.4
Grade 1 or 2	55 (50)	0.026	0.015–0.045		22.5	20.8–25.2
Histopathology	118			0.133			0.002*
IDC	98 (83)	0.030	0.019–0.054		21.6	19.6–23.6
ILC	20 (17)	0.028	0.013–0.049		23.7	21.8–25.9
Molecular subtype	124			0.361			< 0.001*
HER2+ type or triple negative type	33 (27)	0.049	0.028–0.059		19.9	17.9–22.3
Luminal type	91 (73)	0.027	0.017–0.045		22.5	20.7–24.8
Lymph node metastasis status	121			0.467			0.714
Positive	57 (47)	0.030	0.016–0.051		21.9	20.2–23.8
Negative	64 (53)	0.030	0.022–0.055		21.9	19.7–23.8
Oncotype DX recurrence score	45			0.538			0.633
High/intermediate risk	15 (33)	0.032	0.025–0.049		22.2	20.2–24.7
Low risk	30 (67)	0.026	0.015–0.046		21.7	20.4–23.7

MS maximum slope, BAT bolus arrival time, IQR interquartile range, IDC invasive ductal carcinoma, ILC invasive lobular carcinoma
*P < 0.05
^†Data in parentheses are percentages
‡Molecular subtype are classified as follows: triple negative type [hormone receptor negative, HER2 negative], HER2 type [HER2 positive regardless of the hormone receptor positivity/negativity], or luminal type [hormone receptor positive, HER2 negative]

ISSN: 1465-542X