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Table 3 Summary of clinical response from baseline to week 24

From: Efficacy of neoadjuvant endocrine therapy compared with neoadjuvant chemotherapy in pre-menopausal patients with oestrogen receptor-positive and HER2-negative, lymph node-positive breast cancer

 

Treatment group

Low Ki subgroup

High Ki subgroup

Chemotherapy arm (n = 87)

Endocrine therapy arm (n = 87)

Chemotherapy arm (n = 49)

Endocrine therapy arm (n = 48)

Chemotherapy arm (n = 36)

Endocrine therapy arm (n = 37)

Best overall tumour response

 MRI

  CR

14 (16.3%)

2 (2.3%)

6 (12.2%)

1 (2.1%)

7 (19.4%)

1 (2.7%)

  PR

58 (67.4%)

43 (50.6%)

35 (71.4%)

28 (58.3%)

22 (61.1%)

14 (37.8%)

  CR + PR

72 (83.7)

45 (52.9%)

41 (83.7%)

29 (60.4%)

29 (81.1%)

15 (40.5%)

 Calliper

  CR

27 (31%)

17 (19.5%)

12 (24.5%)

10 (20.8%)

8 (22.2%)

13 (35.5%)

  PR

46 (52.9%)

45 (51.5%)

22 (44.9%)

30 (62.5%)

20 (55.6%)

16 (43.2%)

  CR + PR

73 (83.9%)

62 (71.3%)

34 (69.4%)

40 (83.3%)

28 (77.8%)

29 (78.4%)

  1. Data are n (%). CR complete response, PR partial response
  2. Low Ki subgroup: Ki67expression ≤ 20%. High Ki subgroup: Ki67 expression > 20%