Fig. 4From: Antitumor activity of Z-endoxifen in aromatase inhibitor-sensitive and aromatase inhibitor-resistant estrogen receptor-positive breast cancerThe effect of Z-endoxifen on the protein expression of Akt in the setting of letrozole resistance. a Treatment of MCF7LR cells with the indicated treatments for 1 h followed by immunoblotting for detection of phospho and total Akt and the loading control Actin. Images are representative of two independent experiments. b IHC staining of Z-endoxifen-, tamoxifen- (n = 3), and letrozole-treated MCF7LR tumors for p-Akt protein. Images are representative of at least three independent tissue staining. AND, androsteinedione; TAM, tamoxifenBack to article page