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Fig. 3 | Breast Cancer Research

Fig. 3

From: Antitumor activity of Z-endoxifen in aromatase inhibitor-sensitive and aromatase inhibitor-resistant estrogen receptor-positive breast cancer

Fig. 3

The effects of Z-endoxifen and tamoxifen treatment on gene expression in the MCF7LR tumors. a Graph depicting the number of genes significantly upregulated (blue) and downregulated (red) 2.0-fold or greater by the indicated SERM treatments in the MCF7LR tumors compared to letrozole-treated MCF7LR tumors. b Venn diagram of genes whose mRNA expression levels were significantly altered by 2.0-fold or greater in Z-endoxifen- or tamoxifen-treated MCF7LR tumors compared to letrozole-treated MCF7LR tumors. c Gene expression of AREG, PGR, and TFF1 as analyzed by quantitative polymerase chain reaction (performed in triplicate wells per gene) in Z-endoxifen- or tamoxifen-treated MCF7LR tumors compared to letrozole-treated MCF7LR tumors. Data is representative of three wells per gene performed in biological duplicates and presented as mean ± SD. Difference in gene expression in the SERM-treated MCF7LR tumors compared to letrozole-treated tumors that are normalized to 1.0 were compared by one sample t test. AREG, Amphiregulin; PGR, progesterone; TFF1, Trefoil factor 1. ns, P > 0.05; *P < 0.05; **P < 0.01; ***P < 0.001 compared to letrozole treatment

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Breast Cancer Research

ISSN: 1465-542X

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