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Table 2 Patient and tumor characteristics based on IHC expression of IR, IGF-1R, and IR/IGF-1R ratio

From: Insulin resistance contributes to racial disparities in breast cancer prognosis in US women

 IRIGF1RIR/IGF1R
LowHighp valueLowHighp value< 11> 1p value
Number of cases (%)84 (43%)112 (57%) 68 (35%)128 (65%) 101 (52%)64 (33%)30 (15%) 
Age (mean ± SD, years)58.7 ± 11.458.7 ± 12.90.98558.9 ± 12.458.6 ± 12.20.86258.1 ± 12.160.0 ± 11.357.5 ± 14.70.530
Race  0.004  0.430   0.003
 White77 (48%)85 (52%) 54 (33%)108 (67%) 89 (55%)54 (34%)18 (11%) 
 Black7 (21%)27 (79%) 14 (41%)20 (59%) 12 (35%)10 (29%)12 (35%) 
Metabolic characteristics
 BMI (mean ± SD)26.6 ± 5.728.2 ± 6.90.09128.0 ± 5.727.2 ± 6.90.46126.5 ± 6.427.7 ± 6.730.0 ± 5.70.039
 Waist circumference (mean ± SD)93.1 ± 15.2100.4 ± 14.70.00296.1 ± 14.598.0 ± 15.80.43895.6 ± 15.299.3 ± 15.6100.3 ± 13.20.203
 HOMA-IR score, (mean ± SD)1.2 ± 1.11.3 ± 1.10.6351.3 ± 1.11.3 ± 1.10.6491.2 ± 1.11.3 ± 1.01.6 ± 1.30.321
Tumor characteristics
 TNBC3 (27%)8 (73%)0.3636 (55%)5 (45%)0.1912 (18%)6 (55%)3 (27%)0.051
 ER positive69 (41%)99 (59%)0.39149 (29%)119 (71%)< .00196 (57%)47 (28%)24 (14%)< .001
 HER2 positive4 (33%)8 (67%)0.5658 (67%)4 (33%)0.0253 (25%)4 (33%)5 (42%)0.032
 NPI (mean ± SD)3.6 ± 0.83.8 ± 1.00.1674.1 ± 0.83.6 ± 1.0< .0013.5 ± 1.03.9 ± 0.84.2 ± 0.8< .001
 iNPI (mean ± SD)3.0 ± 1.13.2 ± 1.20.4433.6 ± 1.12.9 ± 1.1< .0012.8 ± 1.23.3 ± 1.13.8 ± 1.1< .001