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Table 2 Patient and tumor characteristics based on IHC expression of IR, IGF-1R, and IR/IGF-1R ratio

From: Insulin resistance contributes to racial disparities in breast cancer prognosis in US women

  IR IGF1R IR/IGF1R
Low High p value Low High p value < 1 1 > 1 p value
Number of cases (%) 84 (43%) 112 (57%)   68 (35%) 128 (65%)   101 (52%) 64 (33%) 30 (15%)  
Age (mean ± SD, years) 58.7 ± 11.4 58.7 ± 12.9 0.985 58.9 ± 12.4 58.6 ± 12.2 0.862 58.1 ± 12.1 60.0 ± 11.3 57.5 ± 14.7 0.530
Race    0.004    0.430     0.003
 White 77 (48%) 85 (52%)   54 (33%) 108 (67%)   89 (55%) 54 (34%) 18 (11%)  
 Black 7 (21%) 27 (79%)   14 (41%) 20 (59%)   12 (35%) 10 (29%) 12 (35%)  
Metabolic characteristics
 BMI (mean ± SD) 26.6 ± 5.7 28.2 ± 6.9 0.091 28.0 ± 5.7 27.2 ± 6.9 0.461 26.5 ± 6.4 27.7 ± 6.7 30.0 ± 5.7 0.039
 Waist circumference (mean ± SD) 93.1 ± 15.2 100.4 ± 14.7 0.002 96.1 ± 14.5 98.0 ± 15.8 0.438 95.6 ± 15.2 99.3 ± 15.6 100.3 ± 13.2 0.203
 HOMA-IR score, (mean ± SD) 1.2 ± 1.1 1.3 ± 1.1 0.635 1.3 ± 1.1 1.3 ± 1.1 0.649 1.2 ± 1.1 1.3 ± 1.0 1.6 ± 1.3 0.321
Tumor characteristics
 TNBC 3 (27%) 8 (73%) 0.363 6 (55%) 5 (45%) 0.191 2 (18%) 6 (55%) 3 (27%) 0.051
 ER positive 69 (41%) 99 (59%) 0.391 49 (29%) 119 (71%) < .001 96 (57%) 47 (28%) 24 (14%) < .001
 HER2 positive 4 (33%) 8 (67%) 0.565 8 (67%) 4 (33%) 0.025 3 (25%) 4 (33%) 5 (42%) 0.032
 NPI (mean ± SD) 3.6 ± 0.8 3.8 ± 1.0 0.167 4.1 ± 0.8 3.6 ± 1.0 < .001 3.5 ± 1.0 3.9 ± 0.8 4.2 ± 0.8 < .001
 iNPI (mean ± SD) 3.0 ± 1.1 3.2 ± 1.2 0.443 3.6 ± 1.1 2.9 ± 1.1 < .001 2.8 ± 1.2 3.3 ± 1.1 3.8 ± 1.1 < .001