Fig. 2

Overall responses of 15 TNBC PDX models to Pan-HER therapy. Low passage TNBC PDX tumor samples were transferred into the right mammary fat pad of mice for engraftment. Once tumors reached an average size of 100–200 mm³, mice were randomized (n ≥ 6 per group) and used to determine the response to the treatment. Regimen treatment design followed three, 1-week cycles consisting of IP injection three times/week of either formulation buffer (vehicle control) or Pan-HER (50 mg/kg). Mouse weight was recorded and tumor volumes measured and calculated, as described in “Methods”, twice weekly. Tumor volume fold change was calculated based on the baseline tumor volumes for each arm. Two-way ANOVA was used for statistical analysis