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Table 1 Molecular functions, cellular components, pathways, and diseases enriched in genes deregulated in fibroblasts following in utero BPA exposure

From: In utero estrogenic endocrine disruption alters the stroma to increase extracellular matrix density and mammary gland stiffness

 

p-value

Molecular Function

 Extracellular matrix structural constituent conferring tensile strength

4.02E-08

 Extracellular matrix structural constituent

1.63E-07

 Voltage-gated calcium channel activity involved in AV node cell action potential

1.54E-05

 Collagen binding

3.20E-05

Cellular Component

 Extracellular matrix

4.87E-09

 Collagen-containing extracellular matrix

5.35E-09

 Extracellular matrix component

1.41E-07

Pathway

 

 Extracellular matrix and extracellular matrix-associated proteins

8.92E-10

 Extracellular matrix organization

3.09E-08

 Integrin signaling pathway

5.81E-08

 NCAM1 interactions

1.21E-07

 Core extracellular matrix including ECM glycoproteins, collagens and proteoglycans

2.07E-07

 ECM-receptor interaction

2.54E-07

 Genes encoding collagen proteins

2.97E-07

 Collagen chain trimerization

4.17E-07

 Collagen biosynthesis and modifying enzymes

3.11E-06

Disease

 

 Colorectal cancer

9.22E-10

 Breast or pancreatic cancer

9.99E-10

 Breast or ovarian cancer

1.39E-09

 Development of vasculature

1.73E-09

 Angiogenesis

1.89E-09

 Breast or gynecological cancer

6.34E-09