Table 2 Sensitivity of mES cells expressing BRCA2 variants to different DNA-damaging agents
Variants | MMS | Mitomycin C | Cisplatin | Camptothecin | Olaparib | IR |
|---|---|---|---|---|---|---|
A262T | No | No | No | No | Yes (mild) | No |
I785V | No | No | No | No | No | No |
N830D | No | No | No | No | No | No |
K2077N | No | No | No | No | No | No |
P3039P | NA | NA | NA | NA | NA | NA |