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Table 2 Sensitivity of mES cells expressing BRCA2 variants to different DNA-damaging agents

From: Functional evaluation of five BRCA2 unclassified variants identified in a Sri Lankan cohort with inherited cancer syndromes using a mouse embryonic stem cell-based assay

VariantsMMSMitomycin CCisplatinCamptothecinOlaparibIR
A262TNoNoNoNoYes (mild)No
I785VNoNoNoNoNoNo
N830DNoNoNoNoNoNo
K2077NNoNoNoNoNoNo
P3039PNANANANANANA
  1. NA not available, mES mouse embryonic stem cells, MMS methyl methanesulfonate, IR γ-irradiation