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Table 6 Comparison of the infiltration of immune cell subsets in pure DCIS, DCIS with microinvasion, and DCIS associated with invasive carcinoma

From: Immune microenvironment in ductal carcinoma in situ: a comparison with invasive carcinoma of the breast

Hormone receptor statusSubset of immune cellsPure DCIS (n = 231)DCIS-M (n = 81)DCIS-INV (n = 90)p value
Three groups*Pure DCIS vs. DCIS-M#Pure DCIS vs. DCIS-INV#DCIS-M vs. DCIS-INV#
All (n = 402)CD4+ TIL19.3 (4.0–47.8)46.3 (16.7–112.1)38.5 (12.0–101.8)< 0.001< 0.001< 0.0011.000
CD8+ TIL12.3 (5.3–25.0)18.7 (6.3–47.8)18.0 (5.5–44.3)0.0270.0570.1681.000
FOXP3+ TIL0 (0–1.0)1.5 (0.0–10.0)1.0 (0.0–3.3)< 0.001< 0.001< 0.0011.000
PD-L1+ IC34/221 (15.4)20/78 (25.6)19/90 (21.1)0.1110.1290.6691.000
Positive (n = 311)CD4+ TIL17.0 (3.7–43.3)18.3 (6.7–85.7)18.0 (10.0–65.0)0.0400.6060.0511.000
CD8+ TIL11.7 (5.3–22.0)15.3 (5.2–34.7)11.0 (3.0–33.0)0.6841.0001.0001.000
FOXP3+ TIL0.0 (0.0–0.0)0.0 (0.0–2.0)1.0 (0.1–2.0)< 0.0010.225< 0.0010.573
PD-L1+ IC26/196 (13.3)6/38 (15.8)9/67 (13.4)0.9161.0001.0001.000
Negative (n = 91)CD4+ TIL35.0 (18.0–86.5)63.3 (31.7–115.0)101.0 (53.0–185.0)0.0010.0360.0030.063
CD8+ TIL22.7 (9.2–48.8)25.7 (9.0–64.0)45.0 (23.0–81.0)0.0071.0000.0090.027
FOXP3+ TIL1.0 (0.0–5.0)4.0 (1.0–12.0)4.0 (1.0–6.0)0.0760.1140.1591.000
PD-L1+ IC8/25 (32.0)14/40 (35.0)10/23 (43.5)0.6901.0001.0001.000
  1. *For the comparison of three groups, the Kruskal-Wallis test or chi-square test was used
  2. #For the comparison of two groups, the Mann-Whitney U test or chi-square test was used. Corrections for multiple testing are performed with the Bonferroni method, and adjusted (adj.) p values are presented
  3. Data are presented as median (interquartile range) for CD4+, CD8+, and FOXP3+ TILs and as frequency (%) for PD-L1+ IC
  4. TIL tumor-infiltrating lymphocyte, IC immune cell, DCIS ductal carcinoma in situ, DCIS-M DCIS with microinvasion, DCIS-INV DCIS associated with invasive carcinoma