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Table 5 Comparison of immune cell infiltration in the DCIS and invasive components of individual tumors

From: Immune microenvironment in ductal carcinoma in situ: a comparison with invasive carcinoma of the breast

Hormone receptor statusImmune cell subsetInvasive componentDCIS componentInvasive > DCIS
No. of cases
Invasive < DCIS
No. of cases
Invasive = DCIS
No. of cases
p value
All (n = 90)CD4+ TIL79.5 (42.0–198.5)38.5 (12.0–101.8)69260< 0.001
CD8+ TIL58.5 (26.8–144.3)18.0 (5.5–44.3)71181< 0.001
FOXP3+ TIL4.0 (1.0–12.3)1.0 (0.0–3.3)561618< 0.001
PD-L1+ IC35 (38.9)19 (21.1)16a0b19c/55d< 0.001
Positive (n = 67)CD4+ TIL73.0 (26.0–195.0)18.0 (10.0–65.0)49180< 0.001
CD8+ TIL45.0 (20.0–100.0)11.0 (3.0–33.0)53131< 0.001
FOXP3+ TIL2.0 (0.0–8.0)1.0 (0.1–2.0)41818< 0.001
PD-L1+ IC19 (28.4)9 (13.4)10a0b9c/48d0.002
Negative (n = 23)CD4+ TIL124.0 (70.0–220.0)101.0 (53.0–185.0)15800.584
CD8+ TIL143.0 (84.0–274.0)45.0 (23.0–81.0)18500.004
FOXP3+ TIL10.0 (2.0–13.0)4.0 (1.0–6.0)15800.022
PD-L1+ IC16 (69.6)10 (43.5)6a0b10c/7d0.031
  1. p values were calculated by the Wilcoxon signed rank test or McNemar test
  2. Data are presented as median (interquartile range) for CD4+, CD8+, and FOXP3+ TILs and as number of positive cases (%) for PD-L1 IC
  3. aInvasive (+)/DCIS (−); binvasive (−)/DCIS (+); cinvasive (+)/DCIS (+); dinvasive (−)/DCIS (−)
  4. TIL tumor-infiltrating lymphocyte, IC immune cell, DCIS ductal carcinoma in situ