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Table 4 Comparison of CD4+ and CD8+ tumor-infiltrating lymphocyte infiltration in individual tumors

From: Immune microenvironment in ductal carcinoma in situ: a comparison with invasive carcinoma of the breast

Disease groupHormone receptor statusCD4+ TIL > CD8+ TILCD4+ TIL < CD8+ TILCD4+ TIL = CD8+ TILp value
Pure DCISTotal (n = 224)135 (60.3)88 (39.3)1 (0.4)< 0.001
HR positive (n = 196)116 (59.2)79 (40.3)1 (0.5)< 0.001
HR negative (n = 28)19 (67.9)9 (32.1)0 (0.0)0.016
Invasive carcinomaTotal (n = 358)150 (41.9)208 (58.1)0 (0.0)0.006
HR positive (n = 248)115 (46.4)133 (53.6)0 (0.0)0.580
HR negative (n = 110)35 (31.8)75 (68.2)0 (0.0)< 0.001
  1. p values were calculated by the Wilcoxon signed rank test. Data are presented as number of cases (%)
  2. TIL tumor-infiltrating lymphocyte, DCIS ductal carcinoma in situ