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Table 3 Comparison of immune cell subset infiltration in pure ductal carcinoma in situ and invasive carcinoma

From: Immune microenvironment in ductal carcinoma in situ: a comparison with invasive carcinoma of the breast

Hormone receptor statusImmune cell subsetPure DCIS (n = 231)Invasive carcinoma (n = 359)p value
TotalCD4+ TIL19.3 (4.0–47.8)85.5 (41.0–176.5)< 0.001
CD8+ TIL12.3 (5.3–25.0)91.5 (42.0–199.3)< 0.001
FOXP3+ TIL0 (0–1.0)9.0 (4.0–19.0)< 0.001
PD-L1+ IC34/221 (15.4)153/350 (43.7)< 0.001
PositiveCD4+ TIL17.0 (3.7–43.3)79.0 (38.3–152.0)< 0.001
CD8+ TIL11.7 (5.3–22.0)68.5 (34.0–139.3)< 0.001
FOXP3+ TIL0.0 (0.0–0.0)6.5 (3.0–16.8)< 0.001
PD-L1+ IC26/196 (13.3)72/242 (29.8)< 0.001
NegativeCD4+ TIL35.0 (18.0–86.5)125.0 (48.8–209.3)< 0.001
CD8+ TIL22.7 (9.2–48.8)160.0 (81.8–278.3)< 0.001
FOXP3+ TIL1.0 (0.0–5.0)15.0 (7.0–28.0)< 0.001
PD-L1+ IC8/25 (32.0)81/108 (75.0)< 0.001
  1. For CD4+, CD8+ and FOXP3+ TILs, p values were calculated by the Mann-Whitney U test, and data are presented as median (interquartile range)
  2. For PD-L1+ IC, p values were calculated by chi-square or Fisher’s exact test, and data are presented as frequency (%)
  3. TIL tumor-infiltrating lymphocyte, IC immune cell, DCIS ductal carcinoma in situ