Skip to main content

Advertisement

Table 1 Clinicopathologic characteristics of pure ductal carcinoma in situ (DCIS) and DCIS with microinvasion

From: Immune microenvironment in ductal carcinoma in situ: a comparison with invasive carcinoma of the breast

Clinicopathologic characteristicsPure DCIS (n = 231)DCIS with microinvasion (n = 81)p value
Age (years)Median (range)47 (25–88)48 (26–76)0.556
Extent of DCIS (cm)Median (range)2.5 (0.4–12.2)4.2 (0.9–14.5)< 0.001
Nuclear gradeLow16 (6.9)2 (2.5)< 0.001
Intermediate129 (55.8)20 (24.7) 
High86 (37.2)59 (72.8) 
Comedo-type necrosisAbsent181 (78.4)30 (37.0)< 0.001
Present50 (21.6)51 (63.0) 
ERNegative30 (13.0)42 (51.9)< 0.001
Positive201 (87.0)39 (48.1) 
PRNegative44 (19.0)47 (58.0)< 0.001
Positive187 (81.0)34 (42.0) 
HER2Negative196 (84.8)43 (53.1)< 0.001
Positive35 (15.2)38 (46.9) 
Ki-67 index< 10%171 (74.0)30 (37.0)< 0.001
≥ 10%60 (26.0)51 (63.0) 
P53Negative201 (87.0)51 (63.0)< 0.001
Positive30 (13.0)30 (37.0) 
  1. p values were calculated by the Mann-Whitney U test and chi-square or Fisher’s exact test. Numbers in parentheses indicate column percentage
  2. ER estrogen receptor, PR progesterone receptor, HER2 human epidermal growth factor receptor 2