Table 1 Clinicopathologic characteristics of pure ductal carcinoma in situ (DCIS) and DCIS with microinvasion
Clinicopathologic characteristics | Pure DCIS (n = 231) | DCIS with microinvasion (n = 81) | p value | |
|---|---|---|---|---|
Age (years) | Median (range) | 47 (25–88) | 48 (26–76) | 0.556 |
Extent of DCIS (cm) | Median (range) | 2.5 (0.4–12.2) | 4.2 (0.9–14.5) | < 0.001 |
Nuclear grade | Low | 16 (6.9) | 2 (2.5) | < 0.001 |
Intermediate | 129 (55.8) | 20 (24.7) | Â | |
High | 86 (37.2) | 59 (72.8) | Â | |
Comedo-type necrosis | Absent | 181 (78.4) | 30 (37.0) | < 0.001 |
Present | 50 (21.6) | 51 (63.0) | Â | |
ER | Negative | 30 (13.0) | 42 (51.9) | < 0.001 |
Positive | 201 (87.0) | 39 (48.1) | Â | |
PR | Negative | 44 (19.0) | 47 (58.0) | < 0.001 |
Positive | 187 (81.0) | 34 (42.0) | Â | |
HER2 | Negative | 196 (84.8) | 43 (53.1) | < 0.001 |
Positive | 35 (15.2) | 38 (46.9) | Â | |
Ki-67 index | < 10% | 171 (74.0) | 30 (37.0) | < 0.001 |
≥ 10% | 60 (26.0) | 51 (63.0) |  | |
P53 | Negative | 201 (87.0) | 51 (63.0) | < 0.001 |
Positive | 30 (13.0) | 30 (37.0) | Â | |