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Fig. 8 | Breast Cancer Research

Fig. 8

From: Anillin regulates breast cancer cell migration, growth, and metastasis by non-canonical mechanisms involving control of cell stemness and differentiation

Fig. 8

Downregulation of E-cadherin expression reverses the decreased motility of anillin-deficient breast cancer cells. E-cadherin was transiently depleted in control and anillin-deficient MDA-MB-231 cells by two different siRNAs. a Immunoblotting analysis shows the efficiency of E-cadherin depletion. b,c Representative images and quantification of wound healing in control and anillin-deficient cell monolayers with and without E-cadherin depletion. Scale bar, 100 μm. d,e Representative images and quantification analysis of Matrigel invasion of control and anillin-overexpressing MDA-MB-231 cells transfected with either control or E-cadherin-specific siRNAs. Data are presented as mean ± SE (n = 3); *p < 0.05; **p < 0.001. Scale bar, 50 μm

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