Table 2 Univariate and multivariate analyses
From: NEDD4 expression is associated with breast cancer progression and is predictive of a poor prognosis
a. Univariate and multivariate analyses of associations between clinical parameters, NEDD4 status, and overall survival | |||||
 Overall survival parameter | Comparison | Univariate | Multivariate | ||
HR (95% CI) | P | HR (95% CI) | P | ||
  Age at diagnosis (years) | > 35 vs. ≤ 35 | 0.648 (0.373–1.123) | 0.122 | 0.887 (0.506–1.556) | 0.676 |
  Tumor size (cm) | T2 vs. T1 | 1.087 (0.554–2.135) | 0.808 | 2.166 (1.067–4.397) | 0.032 |
T3 vs. T1 | 1.333 (0.692–2.567) | 0.391 | 1.625 (0.840–3.143) | 0.149 | |
  Tumor grade | 2 vs. 1 | 2.003 (1.333–3.007) | 0.001 | 2.186 (1.443–3.310) | 0.000 |
3 vs. 1 | 0.728 (0.493–1.074) | 0.109 | 1.015 (0.664–1.554) | 0.944 | |
  NEDD4 expression | Post vs. neg | 2.353 (1.550–3.572) | 0.000 | 2.134 (1.394–3.268) | 0.000 |
  Nodal status | Post vs. neg | 2.105 (2.212–4.360) | 0.000 | 2.678 (1.818–3.970) | 0.000 |
b. Univariate and multivariate analyses of associations between clinical parameters, NEDD4 status, and disease-free survival | |||||
 Disease-free survival parameter | Comparison | Univariate | Multivariate | ||
HR (95% CI) | P | HR (95% CI) | P | ||
  Age at diagnosis (years) | > 35 vs. ≤ 35 | 0.671 (0.408–1.105) | 0.117 | 0.957 (0.577–3.167) | 0.865 |
  Tumor size (cm) | T2 vs. T1 | 0.784 (0.466–1.379) | 0.399 | 1.501 (0.831–2.713) | 0.178 |
T3 vs. T1 | 1.205 (0.703–2.065) | 0.497 | 1.482 (0.0.863–2.546) | 0.154 | |
  Tumor grade | 2 vs. 1 | 1.752 (1.222–2.510) | 0.002 | 1.796 (1.246–2.589) | 0.002 |
3 vs. 1 | 0.635 (0.453–0.89) | 0.008 | 1.057 (0.723–1.543) | 0.776 | |
  NEDD4 expression | Post vs. neg | 2.407 (1.667–3.475) | 0.000 | 2.185 (1.507–3.167) | 0.000 |
  Nodal status | Post vs. neg | 3.762 (2.771–5.108) | 0.000 | 3.289 (2.310–4.683) | 0.000 |
c. Univariate and multivariate analyses of associations between clinical parameters and NEDD4 status and disease-free survival of BCLNM | |||||
 Disease-free survival parameter | Comparison | Univariate | Multivariate | ||
HR (95% CI) | P | HR (95% CI) | P | ||
  Age at diagnosis (years) | > 35 vs. ≤ 35 | 1.334 (0.697–2.550) | 0.384 | 1.328 (0.688–2.561) | 0.397 |
  Tumor size (cm) | T2 vs. T1 | 1.455 (0.753–2.811) | 0.265 | 1.142 (0.553–2.356) | 0.720 |
T3 vs. T1 | 1.127 (0.612–2.077) | 0.701 | 1.074 (0.529–1.991) | 0.821 | |
  Tumor grade | 2 vs. 1 | 1.814 (1.162–2.932) | 0.009 | 2.033 (1.293–3.197) | 0.002 |
3 vs. 1 | 1.798 (1.162–2.780) | 0.008 | 1.861 (1.143–3.029) | 0.013 | |
  NEDD4 | Post vs. neg | 2.512 (1.460–4.321) | 0.001 | 2.834 (1.636–4.911) | 0.000 |