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Fig. 5 | Breast Cancer Research

Fig. 5

From: NEDD4 expression is associated with breast cancer progression and is predictive of a poor prognosis

Fig. 5

NEDD4 expression is associated with IGF-1R/Akt pathway a The expression of NEDD4 and PTEN in BC tissue. A TMA containing 148 BC tissue samples was immunohistochemically stained with anti-NEDD4 and anti-PTEN. b The expression of NEDD4 and IGF-1R in BC tissue. A TMA containing 148 BC samples was immunohistochemically stained with anti-NEDD4 and anti-IGF-1R. c The expression of NEDD4 and p-Aktser473 in BC tissue. A TMA containing 148 BC samples was immunohistochemically stained with anti-NEDD4 and anti-p-Aktser473. d Representative immunostaining patterns for serial sections of the same tumor for NEDD4, IGF-1R, and p-Aktser473. e Protein expression level of indicated proteins was detected by western blots in BC cells, with or without NEDD4 knockdown. GAPDH was used as a control. NEDD4, neural precursor cell-expressed developmentally downregulated gene 4; BC, breast cancer; PTEN, phosphatase and tensin homolog; TMA, tissue microarray; IGF-1R, insulin-like growth factor receptor

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