Fig. 2
From: NEDD4 expression is associated with breast cancer progression and is predictive of a poor prognosis
NEDD4 is highly expressed in BC. a The percentage of BC tumors with positive NEDD4 staining was compared to that of ANTs (χ2 test, χ2 = 94.872, P < 0.001). b Representative IHC images of different NEDD4 staining grades in BC tumors and paired ANT. c The median IRS of BC tumors was significantly higher compared to that of ANTs (Mann–Whitney test, P < 0.001). d The median IRS was higher in ER-positive BC tumors compared to ER-negative tumors (Mann–Whitney test, P < 0.001). NEDD4, neural precursor cell-expressed developmentally downregulated gene 4; ANT, adjacent normal tissue; BC, breast cancer; IRS, immunoreactive score; T, tumor; ER, estrogen receptor; IHC, immunohistochemistry