Variable | p value | Hazard ratio | 95% CI for HR | Type of analysis | Type of variable | |
---|---|---|---|---|---|---|
Lower | Upper | |||||
Overall survival analysis | ||||||
 CTC threshold | < 0.0001 | 2.870 | 1.876 | 4.392 | Univariate | Stratified biomarker |
 cfDNA threshold | < 0.0001 | 2.296 | 1.476 | 3.570 | ||
 CA15-3 threshold | < 0.0001 | 2.876 | 1.717 | 4.816 | ||
 AP threshold | < 0.0001 | 3.063 | 1.982 | 4.732 | ||
 CTC threshold | 0.162 | 1.447 | 0.862 | 2.430 | *Multivariate | |
 cfDNA threshold | 0.034 | 1.684 | 1.041 | 2.726 | ||
 CA15-3 threshold | 0.017 | 1.973 | 1.130 | 3.446 | ||
 AP threshold | 0.006 | 1.996 | 1.219 | 3.268 | ||
 CTC count | 0.003 | 1.213 | 1.068 | 1.376 | Univariate | Normalized continuous biomarker |
 cfDNA yield | 0.016 | 1.216 | 1.037 | 1.427 | ||
 CA15-3 levels | 0.001 | 1.278 | 1.110 | 1.472 | ||
 AP levels | < 0.0001 | 1.611 | 1.365 | 1.902 | ||
 CTC count | 0.001 | 1.243 | 1.088 | 1.421 | *Multivariate | |
 cfDNA yield | 0.024 | 1.199 | 1.024 | 1.405 | ||
 CA15-3 levels | 0.168 | 1.120 | 0.953 | 1.315 | ||
 AP levels | < 0.0001 | 1.565 | 1.307 | 1.874 |