Endocrine-responsive lobular carcinoma of the breast: features associated with risk of late distant recurrence

Breast Cancer Research

Table 3 Prognostic factors of late (> 5 years) distant recurrences in ILCs by lymph node status

	pN0 (N = 901)					pN1/2/3 (N = 525)					p value for interaction with pN
	Multivariable analysis					Multivariable analysis
	N	Events/PY	HR	95% CI	p value	N	Events/PY	HR	95% CI	p value
Ki-67 (%)
< 20%	701	15/2584	Ref.			359	37/1462	Ref.
≥ 20%	200	14/812	2.88	1.29–6.45	0.01	166	23/750	1.52	0.85–2.72	0.16	0.06
HER2^a
Not expressed	846	24/3116	Ref.			472	53/1893	Ref.
Intense and complete	26	2/85	3.48	0.80–15.1	0.10	19	1/74	0.52	0.07–3.85	0.52	0.21
Grade^b
G1/2	791	23/2993	Ref.			399	48/1657	Ref.
G3	72	3/279	0.63	0.18–2.18	0.46	63	5/289	0.52	0.21–1.29	0.16	0.19
pT
pT1/2	864	24/3272	Ref.			434	44/1868	Ref.
pT3/4	37	5/125	3.26	1.24–8.57	0.02	91	16/344	2.04	1.15–3.64	0.02	0.09
PgR
< 20%	245	5/1005	Ref.			157	21/722	Ref.
≥ 20%	656	24/2391	1.81	0.69–4.77	0.23	368	39/1490	0.75	0.43–1.32	0.32	0.14

^aTwenty-nine patients pN0 with missing information (3 events/195 PY), 34 patients pN1/2/3 with missing information (6 events/244 PY)
^bThirty-eight patients pN0 with missing information (3 events/124 PY), 63 patients pN1/2/3 with missing information (7 events/266 PY)

ISSN: 1465-542X