Endocrine-responsive lobular carcinoma of the breast: features associated with risk of late distant recurrence

Breast Cancer Research

Table 2 Prognostic factors of early (≤ 5 years) and late (> 5 years) distant recurrences in ILCs, univariable and multivariable analysis

	≤ 5 years					> 5 years								Heterogeneity p value (univariate analyses)
	Univariable analysis					Univariable analysis					Multivariable analysis for late DM (> 5 years)
	N	Distant events/PY	HR	95% CI	p value	N	Distant events/PY	HR	95% CI	p value	HR	95% CI	p value
Ki-67 (%)
< 20%	1375	70/6110	Ref.			1060	52/4046	Ref.			Ref.
≥ 20%	497	46/2165	1.85	1.27–2.68	0.001	366	37/1562	1.81	1.19–2.75	0.005	1.90	1.17–3.07	0.009	0.93
HER2^a
Not expressed	1727	102/7629	Ref.			1318	77/5009	Ref.			Ref.
Intense and complete	72	10/300	2.38	1.26–4.52	0.008	45	3/159	1.13	0.35–3.62	0.84	1.18	0.34–4.06	0.79	0.43
pN
pN0	1103	16/5017	Ref.			901	29/3397	Ref.			Ref.
pN1/2/3	769	100/3259	9.55	5.64–16.2	< 0.001	525	60/2212	3.21	2.06–5.01	< 0.001	2.70	1.68–4.34	< 0.001	0.002
Grade^b
G1/2	1511	64/6767	Ref.			1190	71/4649	Ref.			Ref.
G3	209	27/871	3.24	2.07–5.07	< 0.001	135	8/568	0.89	0.44–1.83	0.76	0.55	0.26–1.16	0.12	0.003
pT
pT1/2	1672	85/7447	Ref.			1298	68/5140	Ref.			Ref.
pT3/4	200	31/828	3.24	2.15–4.90	< 0.001	128	21/468	3.31	2.05–5.33	< 0.001	2.42	1.42–4.12	0.001	0.91
PgR
< 20%	555	57/2392	Ref.			402	26/1727	Ref.			Ref.
≥ 20%	1317	59/5883	0.42	0.29–0.61	< 0.001	1024	63/3881	1.10	0.69–1.74	0.69	1.03	0.64–1.67	0.90	0.001

^aFor patients with HER2, unknown 4 events occurred within the first 5 years of FUP and 9 beyond 5 years
^bFor patients with grade, unknown 25 events occurred within the first 5 years of FUP and 10 beyond 5 years

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