Fig. 5

Elacestrant demonstrates anti-tumor activity as a single agent and in combination with PIK3CA pathway inhibitors. Mean tumor volumes (n = 10/arm) ± SEM of ST3932 (a) and CTG-2432 (b) PDX models in mice treated with indicated treatments. For the ST3932 model, asterisks represent significant differences between vehicle-treated and the indicated groups on the day the first vehicle-treated animal was taken down (day 28). For the CTG-2432 model, asterisks represent significant differences between the indicated groups at the end of the study. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001