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Fig. 1 | Breast Cancer Research

Fig. 1

From: Estrogen receptor coregulator binding modulator (ERX-11) enhances the activity of CDK4/6 inhibitors against estrogen receptor-positive breast cancers

Fig. 1

ERX-11 and palbociclib synergistically reduce the growth of ER+ and endocrine therapy-resistant BCa cells. a Equal numbers of MCF-7 cells were treated with ERX-11 (250 nM), palbociclib (50 nM), or in combination, and clonogenic (survival) assays were performed after 14 days. ZR-75 (b), T-47D (c), MCF-7/LTLT (d), and MCF-7/TamR (e) cells were stimulated with E2 (10−8 M) or androstenedione (10 −8 M) for 7 days in the presence or absence of ERX-11 (0.5 μM), palbociclib (0.5 μM), or in combination, and the cell viability was measured by MTT assay. ZR-75 (f) and MCF-7 (g) cells were stimulated with E2 (108 M) for 7 days in the presence or absence of ERX-11 (31 nM), abemaciclib (31 nM), ribociclib (31 nM), or combination, and the cell viability was measured by MTT assay. The combination index (CI) was determined by the Chou-Talalay method, CI < 1 indicates synergism (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001)

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