Fig. 3
From: Combining RANK/RANKL and ERBB-2 targeting as a novel strategy in ERBB-2-positive breast carcinomas
Dimer formation pattern between RANK and ERBB2 receptor in BC cells. a–d Representative images are shown using confocal microscopy. Red dots represent the positive signal of RANK/ERBB2 heterodimers in SKBR3, MCF7, MDA-MB-453, and BT-474 cells using DUOLINK in situ proximity ligation assay (PLA). Scale bars represent 20 μm. e–h Dot plots represent the total signal per cell as analyzed by Duolink Image Tool Software. Data represent mean ± SD. Asterisks indicate **p < 0.01 and ***p < 0.001 compared to mock cells for each panel