Table 1 Genes whose baseline expression significantly correlated with the change in Ki67 (p < 0.005) based on 155 HER2− of the 178 AI-treated samples
Gene symbol | Entrez gene name | Correlate with change in Ki67 | Correlate with residual Ki67 | ||||
|---|---|---|---|---|---|---|---|
Rank by correlation coefficient (rho) | Rho | Parametric p value | Ranking by rho | Rho | Parametric p value | ||
ESR1 | NA | − 0.11 | 1.70E−01 | NA | − 0.16 | 5.30E−02 | |
Associated with good antiproliferative response | |||||||
ACADVL | Acyl-CoA dehydrogenase very long | 1 | − 0.355 | 6.90E−06 | 1 | − 0.419 | 1.00E−07 |
TRABD | TraB domain containing | 2 | − 0.333 | 2.51E−05 | 208 | − 0.241 | 2.58E−03 |
CCND1 | Cyclin D1 | 3 | − 0.328 | 3.34E−05 | 294 | − 0.226 | 4.69E−03 |
TRIP6 | Thyroid hormone receptor interactor 6 | 4 | − 0.299 | 1.71E−04 | 58 | − 0.286 | 3.18E−04 |
CTTN | Cortactin | 5 | − 0.297 | 1.88E−04 | NA | NA | > 5.00E−3 |
MRPL23 | Mitochondrial ribosomal protein L23 | 6 | − 0.295 | 2.04E−04 | 277 | − 0.228 | 4.44E−03 |
CCNI | Cyclin I | 7 | − 0.289 | 2.81E−04 | 89 | − 0.271 | 6.79E−04 |
EPHX2 | Epoxide hydrolase 2 | 7 | − 0.289 | 2.82E−04 | 8 | − 0.356 | 6.30E−06 |
IMPDH2 | Inosine monophosphate | 9 | − 0.288 | 3.00E−04 | 114 | − 0.264 | 9.45E−04 |
ARHGEF6 | Rac/Cdc42 guanine nucleotide exchange factor 6 | 10 | − 0.283 | 3.70E−04 | NA | NA | > 5.00E−3 |
ACY1 | Aminoacylase 1 | 10 | − 0.283 | 3.73E−04 | 86 | − 0.272 | 6.53E−04 |
EIF3G | Eukaryotic translation initiation factor 3 subunit G | 12 | − 0.282 | 3.91E−04 | 122 | − 0.261 | 1.08E−03 |
GLI3 | GLI family zinc finger 3 | 12 | − 0.282 | 3.97E−04 | 155 | − 0.252 | 1.59E−03 |
TTC17 | Tetratricopeptide repeat domain 17 | 14 | − 0.279 | 4.70E−04 | 6 | − 0.366 | 3.30E−06 |
SCUBE2 | Signal peptide, CUB domain and EGF-like domain containing 2 | 15 | − 0.276 | 5.24E−04 | 3 | − 0.393 | 5.00E−07 |
MRPS27 | Mitochondrial ribosomal protein S27 | 16 | − 0.274 | 5.84E−04 | 245 | − 0.236 | 3.23E−03 |
Associated with poor antiproliferative response | |||||||
PERP | PERP, TP53 apoptosis effector | 1 | 0.291 | 2.53E−04 | 161 | 0.273 | 6.09E−04 |
YWHAQ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta | 2 | 0.29 | 2.63E−04 | 86 | 0.328 | 3.47E−05 |
SNIP1 | Smad nuclear interacting protein 1 | 3 | 0.275 | 5.47E−04 | 210 | 0.26 | 1.15E−03 |
PNO1 | Partner of NOB1 homologue | 4 | 0.274 | 5.74E−04 | 214 | 0.258 | 1.21E−03 |
SEC22B | SEC22 homologue B, vesicle trafficking protein (gene/pseudogene) | 5 | 0.268 | 7.64E−04 | NA | NA | > 5.00E−3 |
GOLT1B | Golgi transport 1B | 5 | 0.268 | 7.92E−04 | 87 | 0.326 | 3.82E−05 |
SAP130 | Sin3A-associated protein 130 | 7 | 0.264 | 9.56E−04 | 285 | 0.24 | 2.65E−03 |
GPKOW | G-patch domain and KOW motifs | 8 | 0.261 | 1.08E−03 | 135 | 0.289 | 2.78E−04 |
NUS1 | NUS1 dehydrodolichyl diphosphate synthase subunit | 9 | 0.259 | 1.19E−03 | 187 | 0.266 | 8.67E−04 |
PLCB1 | Phospholipase C beta 1 | 10 | 0.257 | 1.28E−03 | NA | NA | > 5.00E−3 |
MBIP | MAP3K12 binding inhibitory protein 1 | 11 | 0.256 | 1.34E−03 | NA | NA | > 5.00E−3 |
VCAM1 | Vascular cell adhesion molecule 1 | 12 | 0.254 | 1.50E−03 | 132 | 0.29 | 2.62E−04 |
DNAJC8 | DnaJ heat shock protein family (Hsp40) member C8 | 13 | 0.25 | 1.79E−03 | NA | NA | > 5.00E−3 |
HENMT1 (C1orf59H) | EN methyltransferase 1 | 14 | 0.249 | 1.87E−03 | 201 | 0.261 | 1.08E−03 |
MRPL50 | Mitochondrial ribosomal protein L50 | 15 | 0.246 | 2.07E−03 | NA | NA | > 5.00E−3 |
ODF2 | Outer dense fibre of sperm tails 2 | 16 | 0.245 | 2.15E−03 | NA | NA | > 5.00E−3 |
PIGA | Phosphatidylinositol glycan anchor biosynthesis class A | 16 | 0.245 | 2.16E−03 | 209 | 0.26 | 1.13E−03 |
HDAC4 | Histone deacetylase 4 | 16 | 0.245 | 2.19E−03 | 311 | 0.236 | 3.21E−03 |
NCOA7 | Nuclear receptor coactivator 7 | 16 | 0.245 | 2.21E−03 | NA | NA | > 5.00E−3 |