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Table 1 Genes whose baseline expression significantly correlated with the change in Ki67 (p < 0.005) based on 155 HER2− of the 178 AI-treated samples

From: Impact of aromatase inhibitor treatment on global gene expression and its association with antiproliferative response in ER+ breast cancer in postmenopausal patients

Gene symbolEntrez gene nameCorrelate with change in Ki67Correlate with residual Ki67
Rank by correlation coefficient (rho)RhoParametric p valueRanking by rhoRhoParametric p value
ESR1 NA− 0.111.70E−01NA− 0.165.30E−02
Associated with good antiproliferative response
 ACADVLAcyl-CoA dehydrogenase very long1− 0.3556.90E−061− 0.4191.00E−07
 TRABDTraB domain containing2− 0.3332.51E−05208− 0.2412.58E−03
 CCND1Cyclin D13− 0.3283.34E−05294− 0.2264.69E−03
 TRIP6Thyroid hormone receptor interactor 64− 0.2991.71E−0458− 0.2863.18E−04
 CTTNCortactin5− 0.2971.88E−04NANA> 5.00E−3
 MRPL23Mitochondrial ribosomal protein L236− 0.2952.04E−04277− 0.2284.44E−03
 CCNICyclin I7− 0.2892.81E−0489− 0.2716.79E−04
 EPHX2Epoxide hydrolase 27− 0.2892.82E−048− 0.3566.30E−06
 IMPDH2Inosine monophosphate9− 0.2883.00E−04114− 0.2649.45E−04
 ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor 610− 0.2833.70E−04NANA> 5.00E−3
 ACY1Aminoacylase 110− 0.2833.73E−0486− 0.2726.53E−04
 EIF3GEukaryotic translation initiation factor 3 subunit G12− 0.2823.91E−04122− 0.2611.08E−03
 GLI3GLI family zinc finger 312− 0.2823.97E−04155− 0.2521.59E−03
 TTC17Tetratricopeptide repeat domain 1714− 0.2794.70E−046− 0.3663.30E−06
 SCUBE2Signal peptide, CUB domain and EGF-like domain containing 215− 0.2765.24E−043− 0.3935.00E−07
 MRPS27Mitochondrial ribosomal protein S2716− 0.2745.84E−04245− 0.2363.23E−03
Associated with poor antiproliferative response
 PERPPERP, TP53 apoptosis effector10.2912.53E−041610.2736.09E−04
 YWHAQTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta20.292.63E−04860.3283.47E−05
 SNIP1Smad nuclear interacting protein 130.2755.47E−042100.261.15E−03
 PNO1Partner of NOB1 homologue40.2745.74E−042140.2581.21E−03
 SEC22BSEC22 homologue B, vesicle trafficking protein (gene/pseudogene)50.2687.64E−04NANA> 5.00E−3
 GOLT1BGolgi transport 1B50.2687.92E−04870.3263.82E−05
 SAP130Sin3A-associated protein 13070.2649.56E−042850.242.65E−03
 GPKOWG-patch domain and KOW motifs80.2611.08E−031350.2892.78E−04
 NUS1NUS1 dehydrodolichyl diphosphate synthase subunit90.2591.19E−031870.2668.67E−04
 PLCB1Phospholipase C beta 1100.2571.28E−03NANA> 5.00E−3
 MBIPMAP3K12 binding inhibitory protein 1110.2561.34E−03NANA> 5.00E−3
 VCAM1Vascular cell adhesion molecule 1120.2541.50E−031320.292.62E−04
 DNAJC8DnaJ heat shock protein family (Hsp40) member C8130.251.79E−03NANA> 5.00E−3
 HENMT1 (C1orf59H)EN methyltransferase 1140.2491.87E−032010.2611.08E−03
 MRPL50Mitochondrial ribosomal protein L50150.2462.07E−03NANA> 5.00E−3
 ODF2Outer dense fibre of sperm tails 2160.2452.15E−03NANA> 5.00E−3
 PIGAPhosphatidylinositol glycan anchor biosynthesis class A160.2452.16E−032090.261.13E−03
 HDAC4Histone deacetylase 4160.2452.19E−033110.2363.21E−03
 NCOA7Nuclear receptor coactivator 7160.2452.21E−03NANA> 5.00E−3
  1. The genes of top rank 16 that associated with good antiproliferative response and the genes of top rank 16 that associated with poor antiproliferative response, plus ESR1. All the 123 genes showing a significant correlation with the change in Ki67 are shown in Additional file 2: Table S5