Fig. 3

Volcano plot highlighting the genes that were identified differentially expressed (p < 0.005) after AI treatment. Based on the difference of the expression mean changes (log2^{(Surgery/Baseline)}) of paired samples between AI-treated and control. a Nine hundred ninety genes (n = 363 upregulated, n = 627 downregulated) in HER2− tumours (902 annotated genes). Number of AI-treated pairs, n = 135; control pairs, n = 46. b Eighty genes (n = 20 upregulated, n = 60 downregulated) in HER2+ tumours (71 annotated genes). Number of AI-treated pairs, n = 22; control pairs, n = 8. The p values range from 1 to a limited minimum value of 1.0E−07 was shown on the y-axis in a scale of −log₁₀^{(p value)}