Fig. 2

Effect of vistusertib on RTKs and downstream signalling pathways. a Schematic representation of the PI3K/AKT/mTOR signalling pathway and cross-talk with RTKs. b Effect of vistusertib alone on in combination with fulvestrant on mTORC1, mTORC2, cell cycle, ER and RTK targets, both in the presence and in the absence of 0.01 nM E2